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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
CIB-3b
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
124811-87-6
纯度：>98% by HPLC ,；NMR (Conforms)
分子式：C14H15NO4
分子量：261.28
溶剂：DMSO (25 mg/ml) Ethanol (30 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：Inhibitor of microRNA biogenesis
Function / Pharmacology：CIB-3b inhibits microRNA (miRNA) biogenesis via binding (KD = 10.42 nM) to transactivation response (TAR) RNA-binding protein 2 (TRBP), disrupting the TRBP-Dicer interaction, a critical element in pre-miRNA processing. It inhibited mi-R21 (EC50 = 1.38 µM) expression, a potent inducer of cellular EMT progression. CIB-3b inhibited hepatocarcinogenesis by blocking EMT in a mouse orthotopic transplantation model (SK-HEP-1 cells).
分子式：C14H15NO4
分子量：261.28
溶剂：DMSO (25 mg/ml) Ethanol (30 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：Inhibitor of microRNA biogenesis
Function / Pharmacology：CIB-3b inhibits microRNA (miRNA) biogenesis via binding (KD = 10.42 nM) to transactivation response (TAR) RNA-binding protein 2 (TRBP), disrupting the TRBP-Dicer interaction, a critical element in pre-miRNA processing. It inhibited mi-R21 (EC50 = 1.38 µM) expression, a potent inducer of cellular EMT progression. CIB-3b inhibited hepatocarcinogenesis by blocking EMT in a mouse orthotopic transplantation model (SK-HEP-1 cells).
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124811-87-6
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