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- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
NOTUMib-1
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
Unknown
纯度：98% by TLC；NMR (Conforms)
分子式：C18H16N2O2
分子量：292.33
溶剂：DMSO (25 mg/ml) Ethanol (5 mg/ml)
性状：Beige solid
存储：-20°C
Activity (short version)：NOTUM inhibitor, restores Wnt signaling
Function / Pharmacology：NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling1. NOTUMib-1 inhibits the carboxylesterase activity of NOTUM, IC50=0.085 M, and restores Wnt signaling. An important new tool for use in cellular disease models in which overactivity of NOTUM suppresses Wnt activity2. NOTUM inhibitors have potential as new therapeutics for degenerative diseaes3.
分子式：C18H16N2O2
分子量：292.33
溶剂：DMSO (25 mg/ml) Ethanol (5 mg/ml)
性状：Beige solid
存储：-20°C
Activity (short version)：NOTUM inhibitor, restores Wnt signaling
Function / Pharmacology：NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling1. NOTUMib-1 inhibits the carboxylesterase activity of NOTUM, IC50=0.085 M, and restores Wnt signaling. An important new tool for use in cellular disease models in which overactivity of NOTUM suppresses Wnt activity2. NOTUM inhibitors have potential as new therapeutics for degenerative diseaes3.
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文献和实验该产品被引用文献
Unknown
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NOTUMib-1
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