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- 2025年07月07日
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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Tafamidis
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
594839-88-0
纯度：98% by TLC；NMR (Conforms)
分子式：C14H7Cl2NO3
分子量：308.12
溶剂：DMSO (20 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：Transthyretin stabilizer
Function / Pharmacology：A potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 M).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.
分子式：C14H7Cl2NO3
分子量：308.12
溶剂：DMSO (20 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：Transthyretin stabilizer
Function / Pharmacology：A potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 M).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.
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文献和实验该产品被引用文献
594839-88-0
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