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- 文献和实验
- 技术资料
- 保存条件：
RT
- 保质期：
咨询
- 英文名：
KL-001
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
309928-48-1
纯度：98% by TLC,；NMR (Conforms)
分子式：C21H22N2O4S
分子量：398.46
溶剂：DMSO (100 mg/ml) Ethanol (20 mg/ml)
性状：White solid
存储：RT
Activity (short version)：Cryptochrome (CRY) activator
Function / Pharmacology：A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes1. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure2. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.
分子式：C21H22N2O4S
分子量：398.46
溶剂：DMSO (100 mg/ml) Ethanol (20 mg/ml)
性状：White solid
存储：RT
Activity (short version)：Cryptochrome (CRY) activator
Function / Pharmacology：A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes1. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure2. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.
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文献和实验该产品被引用文献
309928-48-1
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KL-001
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