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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
24(S)-Hydroxycholesterol
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
474-73-7
纯度：99% by HPLC,；NMR (Conforms)
分子式：C27H46O2
分子量：402.66
溶剂：DMSO (10 mg/ml) Ethanol (10 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：Endogenous cholesterol metabolite
Function / Pharmacology：24(S)-Hydroxycholesterol is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in neuroblastoma cells3, possibly via a necroptosis pathway4. 24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM).5 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications.6,7 It was also able to reduce Aβ production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.7
分子式：C27H46O2
分子量：402.66
溶剂：DMSO (10 mg/ml) Ethanol (10 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：Endogenous cholesterol metabolite
Function / Pharmacology：24(S)-Hydroxycholesterol is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in neuroblastoma cells3, possibly via a necroptosis pathway4. 24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM).5 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications.6,7 It was also able to reduce Aβ production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.7
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文献和实验该产品被引用文献
474-73-7
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24(S)-Hydroxycholesterol
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