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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Zileuton
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
111406-87-2
纯度：>98%,；NMR (Conforms)
分子式：C11H12N2O2S
分子量：236.29
溶剂：DMSO (25 mg/ml)
性状：white solid
存储：-20°C
Activity (short version)：5-LO inhibitor
Function / Pharmacology：Zileuton is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50’s = 400nM rat PMNL, 400nM human PMNL and 900nM human whole blood).1 Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 µM PGE2 inhibition in LPS-stimulated whole blood).2 Zileuton was approved by the FDA in 1997 for the treatment of asthma (ZYFLO).
分子式：C11H12N2O2S
分子量：236.29
溶剂：DMSO (25 mg/ml)
性状：white solid
存储：-20°C
Activity (short version)：5-LO inhibitor
Function / Pharmacology：Zileuton is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50’s = 400nM rat PMNL, 400nM human PMNL and 900nM human whole blood).1 Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 µM PGE2 inhibition in LPS-stimulated whole blood).2 Zileuton was approved by the FDA in 1997 for the treatment of asthma (ZYFLO).
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111406-87-2
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