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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Ko-143
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
461054-93-3
纯度：98% by TLC,；NMR (Conforms)
分子式：C26H36N3O5
分子量：470.59
溶剂：DMSO (25 mg/ml) Ethanol (50 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：BCRP inhibitor
Function / Pharmacology：A potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP/ABCG2)1. Reverses resistance of MTX and topotecan at 25 nM in human and mouse cell lines.1 Also inhibits ABCB1 and ABCC1 at concentrations >1 μM.2 Restores the sensitivity of triple negative breast cancer cells to photodynamic therapy.3 Prevents the export of the FAAH inhibitor URB937 from the CNS.4 Forces prostate stem cells to undergo and AR-modulated differentiation to an androgen deprivation therapy-sensitive luminal phenotype.5 Active in vivo.
分子式：C26H36N3O5
分子量：470.59
溶剂：DMSO (25 mg/ml) Ethanol (50 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：BCRP inhibitor
Function / Pharmacology：A potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP/ABCG2)1. Reverses resistance of MTX and topotecan at 25 nM in human and mouse cell lines.1 Also inhibits ABCB1 and ABCC1 at concentrations >1 μM.2 Restores the sensitivity of triple negative breast cancer cells to photodynamic therapy.3 Prevents the export of the FAAH inhibitor URB937 from the CNS.4 Forces prostate stem cells to undergo and AR-modulated differentiation to an androgen deprivation therapy-sensitive luminal phenotype.5 Active in vivo.
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文献和实验该产品被引用文献
461054-93-3
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Ko-143
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