5-(4,4,5,5-tetramethyl-1,3,2-d

Two‐Step, One‐Pot Synthesis of Inosine, Guanosine, and 2′‐Deoxyguanosine O6‐Ethers via Intermediate O6‐(Benzotriazol‐1‐yl) Derivatives

for the etherification at the O 6 ?position of silyl?protected inosine, guanosine, and 2??deoxyguanosine is described. Typically, a THF solution of the silylated nucleoside is treated with 1H ?benzotriazol?1?yloxy?tris(dimethylamino)phosphonium hexafluorophosphate (BOP

Synthesis of Peptidomimetic Conjugates of Cyclic Nucleoside Phosphonates

3 ) Benzotriazol‐1‐yl‐oxytripyrrolidinophosphonium hexafluorophosphate (PyBOP; Aldrich) Diethylether (Et 2 O), ACS reagent grade

Biotinylation of a Propargylated Cyclic (3′‐5′) Diguanylic Acid and of Its Mono‐6‐Thioated Analog Under “Click” Conditions

12 from the biotinylated azide 11 . Abbreviations: TBTA, tris ‐(benzyltriazolylmethyl)amine; Gua, guanin‐9‐yl. Adapted with permission from Grajkowski et al. (). Copyright 2010 American Chemical Society.