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- 文献和实验
- 技术资料
- 保存条件：
Recommended Refrigeration Conditions (2℃-8℃) for storage
- 英文名：
5-bromo-3-fluoro-1-methyl-pyrazole
- 供应商：
南京鼎石
- CAS号：
1780764-54-6
- 规格：
10g///25g///50g///100g///250g///500g///1kg///5kg///944kg
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文献和实验Treating Respiratory Viral Diseases with Chemically Modified, Second Generation Intranasal siRNAs
) that were chemically modified and screened for improved stability, activity and pharmacokinetics. 2′-O -methyl (2′-O -Me) and 2′-deoxy-2′-fluoro (2′-F) substitutions in the ribose ring were incorporated in different positions of the sense and antisense strands
to replace combinattons of leucme coupled with valine in pepttde sequences. The preparation described is the final method developed, after many early less successful attempts. The synthesis mvolves (Fig. 1 ) the coupling of 1-bromo-5-methyl-2-hexene 3 and N
, the ultraviolet (UV) (9 –12 ), and the postcolumn UV derivatization with 4,4′-dithiopyridine (13 ) and 5,5-dithiobis (2-nitrobenzoic acid) (14 ), the precolumn fluorescence derivatization with 4-(aminosulfonyl)- or ammonium-7-fluoro-2,1,3-benzoxadiazole
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