IgG1 Fc Protein，Human【中文名称：IgG

Capture of the Human IgG1 Antibodies by Protein A for the Kinetic Study of h-IgG/FcR Interaction Using SPR-Based Biosensor Technology

Surface plasmon resonance (SPR) is a key technology to evaluate IgG effector functions in vitro involving binding to Fcgamma receptors (FcγR). We describe here the chemical coupling of protein A to a sensor chip. IgGs prepared

Exploiting Fc Chimaeric Proteins for the Identification of Ligands Specific for the Mannose Receptor

. In this chapter we describe our experience in the use of proteins containing selected regions of the mannose receptor fused to the Fc region of human IgG1 or murine IgG2b. Using these reagents we have discovered new and unexpected ligands for the mannose receptor

免疫球蛋白Fc段受体

　　1.FcγR的结构和分布　FcγR可分为FcγRⅠ、FcγRⅡ和FcγRⅢ三类，它们的结构和分布有所不同。 　　（1）FcγRⅠ（CD64）：70kDa穿膜糖蛋白，属Ig超家族成员，胞膜外区有3个C2结构，基因染色体定位于1q23～24。识别CD64的代表性McAb有McAb22、McAb32.2、197和10.1等FcγRⅠ是高亲合力受体，Kd值为10-8 ～10-9 M，主要与人的单体IgG1、IgG3以及小鼠IgG2a和IgG3结合。与人IgG