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文献和实验p16INK4A and Familial Melanoma
. This phase is controlled by several protein complexes including those consisting of cyclin-dependent kinases (CDK4 and CDK6) and cyclin D. These complexes are inhibited by the INK4 family of proteins—p16INK4A , p15INK4B , p18INK4C , and p19INK4D . Genetic
Altered consciousness Coma Cervical cancer Cause unknown; predisposing factors include intercourse under age 16
couples chromatin sensing to ATM signalling”(Nature,2013);“Human SIRT6 promotes DNA end resection through CtIP deacetylation”(Science,2010)。第一篇文章已被引用119次,研究发现在DNA损伤后,c-Abl激酶磷酸化“酪氨酸44”上的KAT5,增强其与H3K9me3的相互作用,并允许由ATM介导的信号作用来启动DNA损伤检查点。当DNA发生双链断裂时,ATM激酶便被激发
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