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- Hello Bio
- 英国
- HB3485
- 2025年12月22日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 英文名：
Recombinant human BDNF protein
- 供应商：
Hello Bio
- 规格：
2μg///10μg
BDNF (Brain-derived neurotrophic factor) is a member of the neurotrophin growth factor family and is highly expressed in the brain. BDNF activates the TrkB and p75 (P75NTR) neurotrophin receptors.
BDNF plays an important role in brain development, physiology and pathology. Dysregulation of BDNF signaling is involved in several neurodegenerative disorders and BDNF also exerts effects on appetite, anxiety, cognition, reward and learning and memory.
Synaptic transmission and plasticity
BDNF is involved in the regulation of synaptic transmission and activity-dependent synaptic plasticity by both pre- and post- synaptic mechanisms. BDNF appears to strengthen excitatory (glutamtergic) synapses and weaken inhibitory (GABAergic) synapses.
BDNF contributes to adaptive neuronal responses such as LTP (long-term potentiation), LTD (long-term depression) and certain forms of short-term synaptic plasticity.
Neurogenesis
BDNF is an important regulator of neurogenesis and plays an important role in the developmental processes. BDNF has growth- and survival- promoting actions on various neurons, including dorsal root ganglion (DRG) cells and hippocampal and cortical neurons.
Stem Cells
BDNF, GDNF and other supplements are often used to differentiate hPSC-derived neural progenitor cells into neurons.
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