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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
Anti-ESR1/ER Antibody
- 抗体英文名:
Anti-ESR1/ER Antibody
- 浓度:
0.5 mg/ml
- 应用范围:
Western Blotting
- 宿主:
0
- 克隆性:
Monoclonal
- 保存条件:
-20°C
- 亚型:
IgG2b, kappa
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文献和实验Nature 深度剖析:管坤良与 Alj 组研究成果为何截然相反,Hippo 通路调控乳腺癌的两面性
maintains ER expression and ER+ breast cancer growth 的文章,提出了与上文结果截然相反的结论 —— 抑癌激酶 LATS1/2 反而促进 ESR1(ERα 编码基因)的表达,从而驱动 ER + 乳腺癌的发展。 图片来源:Nature本文作者首先通过 CRISPR 同时敲除了 MCF-7 细胞中的 LATS1/2,然而意外的是,细胞生长竟然停滞了,且 ESR1 mRNA 水平和 ERα 蛋白水平大幅下降。但 Alj 组文章中,LATS1/2 仅在蛋白水平上降解
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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