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文献和实验Chemokine Receptor Antagonist Development
This chapter describes assays that focus on the characterization of compounds identified in high-�throughput screening campaigns, and the subsequent medicinal chemistry programs. They cover methods to determine potency
NPY Antisense Oligodeoxynucleotides to Study the Actions of NPY
in the brain. Their potential usefulness is even greater for the ever increasing number of newly discovered peptide and receptor genes expressed in the central nervous system for which pharmacological blocking agents or selective ligands
Developing a Photoreactive Antagonist
approach for developing small molecules that, upon irradiation with light, may be used to rapidly inactivate targeted proteins expressed on the surfaces of cells. Highlighted is ANQX, a photoreactive AMPA receptor antagonist developed to irreversibly
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