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文献和实验Investigating Central Tolerance With Reaggregate Thymus Organ Cultures
In the thymus, immature CD4+ 8+ thymocytes expressing randomly rearranged T-cell receptor α- and β-chain genes undergo positive and negative selection events based on their ability to recognize self-peptide/major histocompatibility complex
Flow Cytometric Profiling of Mature and Developing Regulatory T Cells in the Thymus
Natural Regulatory T (Treg) cells are a subset of CD4+ T cells characterized by expression of the transcription factor Foxp3 and the ability to suppress immune responses. Treg cells develop in the thymus in response to highly specific
Studying T-Cell Repertoire Selection Using Fetal Thymus Organ Culture
of peptide/MHC on thymic stromal cell by immature thymocytes. We have developed a fetal thymus organ culture (FTOC) system based on transporter associated with antigen processing (TAP) 1-deficient mice to examine the role of peptide/MHC in triggering
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