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文献和实验Sindbis Virus-Based Vectors for the Study of Class I Antigen Presentation In Vitro and In Vivo
Alphavirus-based vectors have received considerable attention in the fields of antigen (Ag) presentation, epitope mapping, vaccinology, and gene therapy (1 -12 ), because of their relative ease of manipulation, purification to high titers
by the expression of major histocompatibility complex (MHC) molecules in the donor organ. Graft microvascular endothelial cells express both HLA class I and class II molecules. They are the first target of the allogeneic response because of their vascular
Studying Ubiquitination of MHC Class I Molecules
proteins which target MHC class I for degradation in the endoplasmic reticulum and at the cell surface. Study of viral-induced MHC class I degradation has been extremely instructive in elucidating cellular pathways for degradation of membrane and secretory
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