InVivoMAb anti-mouse TNFα

Cytokines and Autoimmune Diseases: From the Control of Autoimmune Diseases With Anti-Cytokine Treatment to the Induction of Autoimmunity With Cytokine

The identification of the role of cytokines in inflammatory and autoimmune diseases has led to significant progress in treatment. The best example is probably the beneficial effect of blocking TNFα in an increasing number of inflammatory diseases

Collagen-Induced Arthritis in Mice: A Major Role for Tumor Necrosis Factor-

for multiple cytokines. Of these, TNFα emerged as a valid therapeutic target for rheumatoid arthritis and this led to the setting up of clinical trials of anti-TNFα antibody therapy. Three anti-TNFα biologics (infliximab, etanercept, and adalimumab

Molecular Analysis of Genetic Instability Caused by Chronic Inflammation

TNFα-induced genetic damage. In addition, TNFα treatment alone led to increased malignant transformation of mouse embryo fibroblasts, which could be partially suppressed by antioxidants. Therefore, genetic instability plays an important role