CHO-S（悬浮）细胞系

CHO-S、CHO-S、CHO-S细胞、CHO-S细胞、CHO-S中国仓鼠卵巢细胞

 

Cell line name CHO-S

Synonyms CHO-s; CHOS

Accession CVCL_7183

Resource Identification Initiative To cite this cell line use: CHO-S (RRID:CVCL_7183)

Comments Omics: Deep proteome analysis.

Omics: Genome sequenced.

Omics: miRNA expression profiling.

Derived from site: In situ; Ovary; UBERON=UBERON_0000992.

Cell type: Epithelial cell of ovary; CL=CL_2000064.

Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)

Hierarchy Parent: CVCL_0213 (CHO)

Children:

CVCL_B6JC (C-HAlb) CVCL_A9NY (CHO C1s-/-) CVCL_VP59 (CHO MGAT1-)

CVCL_4386 (CHO-AA8) CVCL_D264 (CHO-AUXB1) CVCL_5A30 (CHO-AUXB3)

CVCL_M722 (CHO-AUXE29) CVCL_WJ93 (CHO-S FUT8-/-) CVCL_A0AT (CHO-S r34.1 (clone D8))

CVCL_5A26 (CHO-S/C0101) CVCL_A0TS (CHO-S/H9C2) CVCL_XF07 (CHO-S/K70E10-1D6)

CVCL_0F81 (CHO-tsH1) CVCL_Y012 (CHOS-XE) CVCL_5J31 (ExpiCHO-S)

CVCL_D604 (FreeStyle CHO-S) CVCL_JG26 (hTf/CHO-S #17) CVCL_JG28 (hTf/CHO-S #29)

CVCL_RN06 (PDIS-14) CVCL_RN10 (PDIS-9) CVCL_EG61 (pREP4 cont/CHO-S #5)

CVCL_A0AU (UCSC.PG128.CHO.S.F4)

Sex of cell Female

Age at sampling Adult

Category Spontaneously immortalized cell line

PubMed=4585080; DOI=10.1016/S0091-679X(08)60052-7

Thompson L.H., Baker R.M.

Isolation of mutants of cultured mammalian cells.

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PubMed=837451; DOI=10.1016/0092-8674(77)90224-0

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Clonal variation in colony morphology and growth of CHO cells cultured on agar.

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DOI=10.3390/pr1030296

Wurm F.M.

CHO quasispecies -- implications for manufacturing processes.

Processes 1:296-311(2013)

 

PubMed=23873082; DOI=10.1038/nbt.2624

Lewis N.E., Liu X., Li Y.-X., Nagarajan H., Yerganian G., O'Brien E., Bordbar A., Roth A.M., Rosenbloom J., Bian C., Xie M., Chen W.-B., Li N., Baycin-Hizal D., Latif H., Forster J., Betenbaugh M.J., Famili I., Xu X., Wang J., Palsson B.O.

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.

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PubMed=26993211; DOI=10.1016/j.jbiotec.2016.03.022

Klanert G., Jadhav V., Shanmukam V., Diendorfer A.B., Karbiener M., Scheideler M., Hernandez-Bort J.A., Grillari J., Hackl M., Borth N.

A signature of 12 microRNAs is robustly associated with growth rate in a variety of CHO cell lines.

J. Biotechnol. 235:150-161(2016)

 

DOI=10.3390/pr5020020

Wurm F.M., Wurm M.J.

Cloning of CHO cells, productivity and genetic stability -- a discussion.

Processes 5:20.1-20.13(2017)

 

PubMed=28876938; DOI=10.1021/acs.jproteome.7b00382

Heffner K.M., Baycin-Hizal D., Yerganian G., Kumar A., Can O., O'Meally R.N., Cole R.N., Chaerkady R., Wu H., Bowen M.A., Betenbaugh M.J.

Lessons from the hamster: Cricetulus griseus tissue and CHO cell line proteome comparison.

J. Proteome Res. 16:3672-3687(2017)

 

PubMed=32985598; DOI=10.1038/s41598-020-72959-8; PMCID=PMC7522264

Heffner K.M., Baycin-Hizal D., Majewska N.I., Kumar S., Dhara V.G., Zhu J., Bowen M.A., Hatton D., Yerganian G., Yerganian A., O'Meally R.N., Cole R.N., Betenbaugh M.J.

Expanded Chinese hamster organ and cell line proteomics profiling reveals tissue-specific functionalities.

Sci. Rep. 10:15841-15841(2020)

 

PubMed=34050613; DOI=10.1002/biot.202100165

Wurm M.J., Wurm F.M.

Naming CHO cells for bio-manufacturing: genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names.

Biotechnol. J. 16:e2100165.1-e2100165.13(2021)

 

PubMed=36610518; DOI=10.1016/j.ymben.2022.12.009; PMCID=PMC11132536

Kotidis P., Donini R., Arnsdorf J., Hansen A.H., Voldborg B.G.R., Chiang A.W.-T., Haslam S.M., Betenbaugh M.J., Jimenez del Val I., Lewis N.E., Krambeck F.J., Kontoravdi C.

CHOGlycoNET: comprehensive glycosylation reaction network for CHO cells.

Metab. Eng. 76:87-96(2023)