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T25
C6/C6细胞系/C6细胞株/C6大鼠神经胶质瘤细胞
Cell line name C6
Synonyms C-6; C 6; RGC-6; RGC6; RGc6
Accession CVCL_0194
Secondary accession CVCL_4060
Resource Identification Initiative To cite this cell line use: C6 (RRID:CVCL_0194)
Comments Doubling time: 14.75 hours (PubMed=2303324); 24-28 hours (DOI=10.5005/jp-journals-10082-02230); ~24 hours (CLS=500142); ~25-30 hours (DSMZ=ACC-550).
Transformant: ChEBI; CHEBI:50102; N-methyl-N-nitrosourea (NMU).
Omics: Deep quantitative proteome analysis.
Omics: Mitochondrial genome sequenced.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Disease Rat malignant glioma (NCIt: C64069)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Wistar Furth; RS=RS:0000982.
Hierarchy Children:
CVCL_ZB60 (C6 rho-0#14) CVCL_1970 (C6-BU-1) CVCL_6336 (C6-SF2)
CVCL_4V35 (C6/ACNU) CVCL_C9FG (C6/Cas9-hyg) CVCL_5657 (C6/lacZ)
CVCL_B7TS (C6rho0) CVCL_5H90 (C6TK-)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications
CLPUB00233
Lightbody J.
Establishment of differentiated clonal strains of glial brain cells in culture.
Fed. Proc. 27:720-720(1968)
PubMed=4873531; DOI=10.1126/science.161.3839.370
Benda P., Lightbody J., Sato G.H., Levine L., Sweet W.H.
Differentiated rat glial cell strain in tissue culture.
Science 161:370-371(1968)
DOI=10.1007/BF02618370
Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)
PubMed=3468959
Yoshida T., Shimizu K., Ushio Y., Mogami H., Sakamoto Y.
Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma.
No To Shinkei 38:1065-1070(1986)
PubMed=2303323
Brauner T., Schmid A., Hulser D.F.
Tumor cell invasion and gap junctional communication. I. Normal and malignant cells confronted in monolayer cultures.
Invasion Metastasis 10:18-30(1990)
PubMed=2303324
Brauner T., Hulser D.F.
Tumor cell invasion and gap junctional communication. II. Normal and malignant cells confronted in multicell spheroids.
Invasion Metastasis 10:31-48(1990)
PubMed=19381449; DOI=10.1007/s11060-009-9875-7; PMCID=PMC2730996
Barth R.F., Kaur B.
Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas.
J. Neurooncol. 94:299-312(2009)
PubMed=25492533; DOI=10.3109/19401736.2014.982619
Gao J., Hu L., Peng H.-H., Shi J.-G.
The complete mitochondrial genome sequence of the rat C6 glioma cell line.
Mitochondrial DNA A. DNA Mapp. Seq. Anal. 27:2188-2189(2016)
DOI=10.5005/jp-journals-10082-02230
Kuduvalli S.S., Ramalakshmi O., Precilla S.D., Anitha T.S.
Evaluation of cell doubling time in C6 and Y79 cell lines based on seeding density.
SBV J. Basic Clin. Appl. Heatlh Sci. 2:146-149(2019)
PubMed=34917708; DOI=10.1016/j.dib.2021.107658; PMCID=PMC8666335
Silantyev A.S., Bukato O.N., Butenko I.O., Chernysheva A.A., Pobeguts O.V., Nosyrev A.E., Gurina O.I.
Proteomic dataset: profiling of glioma C6 and astrocytes rat cell lines before and after co-cultivation.
Data Brief 39:107658.1-107658.9(2021)
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文献和实验*发表【中文论文】请标注：由博辉生物科技（广州）有限公司提供； *发表【英文论文】请标注：From Bohui Biological Technology (Guangzhou) Co., Ltd.
网络 六、C6和C7 C6和C7有许多相似之处，均为单链糖蛋白，且分子量也相近分别为128kDa和121kDa。编码C6和C7分子的基因可能由共同的祖基因进化而来。C6和C7在氨基酸水平上有33.5%的同源性。近几年来，对C6的结构及功能进行了较深入的研究，由cDNA序列推导成熟C6的全部多肽链含有913个氨基残基，前面还有21个独特氨基酸残基
相关专题 Accuri的C6流式细胞仪系统是一种全功能、二激光、六探测器分析流式细胞仪系统，包括：C6流式细胞仪、CFlow软件 、电脑。C6的流式细胞仪系统提供最畅销的流式细胞仪，而且价格少几倍。C6流式细胞仪系统以敏感的探测器捕获和激发前散射光和旁散射光，以及4个荧光探测器的可调光学过滤器。CFlow软件使搜集数据和分析变得简单快速。CFlow软件如此直观，让您启动并运行一个小时内得到您的Accuri系统
edwardellen 求助！！！ 本人菜鸟，最近开始接触凋亡相关信号，在HepG-2中做实验，有一点很困惑，HepG-2中的p53是野生型的还是突变型的？还是两者都存在？查了一些资料，有些文章之间表达的意思模凌两可。困惑啊！ 哪位好心的达人能给我一个确定的答案呢？ 另外，是否有做p53相关的牛人能告诉我P53在哪些实验用肿瘤细胞系中是野生型的，在哪些是突变型的？ 谢谢！谢谢！谢谢！ doctormy
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