MB49细胞系

MB49 /MB49 细胞系/MB49 细胞株/MB49 小鼠膀胱癌细胞

Cell line name    MB49
Synonyms    MB-49
Accession    CVCL_7076
Resource Identification Initiative    To cite this cell line use: MB49 (RRID:CVCL_7076)
Comments    Karyotypic information: Has lost chromosome Y (PubMed=22559978).
Transformant: ChEBI; CHEBI:254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Disease    Mouse bladder transitional cell carcinoma (NCIt: C25823)
Species of origin    Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/ICRF-a(t).
Hierarchy    Children:
CVCL_VL62 (MB49-I)
Sex of cell    Male
Age at sampling    Adult
Category    Cancer cell line
STR profile    Source(s): Millipore=SCC148; Ubigene=YC-C104

Markers:
Mouse STR 1-1    15,16
Mouse STR 1-2    19
Mouse STR 2-1    16
Mouse STR 3-2    13,14
Mouse STR 4-2    20.3
Mouse STR 5-5    17
Mouse STR 6-4    18
Mouse STR 6-7    15
Mouse STR 7-1    26.2
Mouse STR 8-1    16
Mouse STR 11-2    16
Mouse STR 12-1    17
Mouse STR 13-1    17
Mouse STR 15-3    22.3
Mouse STR 17-2    14,15
Mouse STR 18-3    16
Mouse STR 19-2    14
Mouse STR X-1    28 (Ubigene=YC-C104)
28,29 (Millipore=SCC148)

Run an STR similarity search on this cell line
Publications    
PubMed=107359; DOI=10.1093/jnci/62.4.1017
Summerhayes I.C., Franks L.M.
Effects of donor age on neoplastic transformation of adult mouse bladder epithelium in vitro.
J. Natl. Cancer Inst. 62:1017-1023(1979)

PubMed=19539312; DOI=10.1016/j.juro.2009.03.076
Lodillinsky C., Rodriguez V., Vauthay L., Sandes E., Casabe A., Eijan A.M.
Novel invasive orthotopic bladder cancer model with high cathepsin B activity resembling human bladder cancer.
J. Urol. 182:749-755(2009)

PubMed=22559978; DOI=10.1016/j.cancergen.2012.02.002
Fabris V.T., Lodillinsky C., Pampena M.B., Belgorosky D., Lanari C., Eijan A.M.
Cytogenetic characterization of the murine bladder cancer model MB49 and the derived invasive line MB49-I.
Cancer Genet. 205:168-176(2012)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

PubMed=29784854; DOI=10.1158/0008-5472.CAN-18-0173; PMCID=PMC6157276
Saito R., Smith C.C., Utsumi T., Bixby L.M., Kardos J., Wobker S.E., Stewart K.G., Chai S.-J., Manocha U., Byrd K.M., Damrauer J.S., Williams S.E., Vincent B.G., Kim W.Y.
Molecular subtype-specific immunocompetent models of high-grade urothelial carcinoma reveal differential neoantigen expression and response to immunotherapy.
Cancer Res. 78:3954-3968(2018)

PubMed=30867744; DOI=10.3892/ol.2019.9995; PMCID=PMC6396118
Alberto M., Cuello H.A., Gulino C.A., Pifano M., Belgorosky D., Gabri M.R., Eijan A.M., Segatori V.I.
Expression of bladder cancer-associated glycans in murine tumor cell lines.
Oncol. Lett. 17:3141-3150(2019)