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T25
EA.hy926细胞系、EA.hy926细胞株、EA.hy926细胞、EA.hy926细胞、EA.hy926 脐静脉细胞融合
Cell line name EA.hy 926
Synonyms EA. hy 926; EA hy 926; EA-hy926; EAhy 926; EAHY-926; EA.Hy926; EA.hy926; EAhy926; EaHy926; Eahy926
Accession CVCL_3901
Resource Identification Initiative To cite this cell line use: EA.hy 926 (RRID:CVCL_3901)
Comments Group: Space-flown cell line (cellonaut).
Characteristics: Produced by the fusion of A549/8 with human umbilical vein endothelial cells.
Doubling time: 12 hours (PubMed=6407019).
Omics: Transcriptome analysis by microarray.
Anecdotal: Have been flown in space on Shijian-10 and on the ISS in 2016 to study growth and secretion in microgravity (PubMed=28199884; PubMed=30108515; PubMed=30977987).
Misspelling: EA.hy 296; Note=Occasionally.
Misspelling: EA-hy 296; Note=Occasionally.
Misspelling: EA.hy296; Note=Occasionally.
Sequence variations
Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_IY87 (A549/8)
Children:
CVCL_C8WK (EA.hy926-EGFP) CVCL_C8VU (EA.hy926-Luc)
Sex of cell Male
Category Hybrid cell line
PubMed=7791520; DOI=10.1016/0024-3205(95)00227-W
Ahn K., Pan S., Beningo K., Hupe D.
A permanent human cell line (EA.hy926) preserves the characteristics of endothelin converting enzyme from primary human umbilical vein endothelial cells.
Life Sci. 56:2331-2341(1995)
PubMed=12453433; DOI=10.1006/mvre.2002.2434
Unger R.E., Krump-Konvalinkova V., Peters K., Kirkpatrick C.J.
In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R.
Microvasc. Res. 64:384-397(2002)
PubMed=16575254; DOI=10.1097/01.mbc.0000220237.99843.a1
Boerma M., Burton G.R., Wang J.-R., Fink L.M., McGehee R.E. Jr., Hauer-Jensen M.
Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition.
Blood Coagul. Fibrinolysis 17:173-180(2006)
PubMed=26345505; DOI=10.2144/000114326
Lieber D., Hochdorfer D., Stoehr D., Schubert A., Lotfi R., May T., Wirth D., Sinzger C.
A permanently growing human endothelial cell line supports productive infection with human cytomegalovirus under conditional cell growth arrest.
BioTechniques 59:127-136(2015)
PubMed=28199884; DOI=10.1016/j.biomaterials.2017.02.005
Pietsch J., Gass S., Nebuloni S., Echegoyen D., Riwaldt S., Baake C., Bauer J., Corydon T.J., Egli M., Infanger M., Grimm D.
Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CRS-8 ISS space mission -- the SPHEROIDS project.
Biomaterials 124:126-156(2017)
PubMed=30108515; DOI=10.3389/fphys.2018.01025; PMCID=PMC6079262
Li N., Wang C.-Z., Sun S.-J., Zhang C., Lu D.-Y., Chen Q., Long M.
Microgravity-induced alterations of inflammation-related mechanotransduction in endothelial cells on board SJ-10 satellite.
Front. Physiol. 9:1025.1-1025.15(2018)
PubMed=30977987; DOI=10.33594/000000071
Kruger M., Pietsch J., Bauer J., Kopp S., Carvalho D.T.O., Baatout S., Moreels M., Melnik D., Wehland M., Egli M., Sahana J., Kobbero S.D., Corydon T.J., Nebuloni S., Gass S., Evert M., Infanger M., Grimm D.
Growth of endothelial cells in space and in simulated microgravity -- a comparison on the secretory level.
Cell. Physiol. Biochem. 52:1039-1060(2019)
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文献和实验*发表【中文论文】请标注：由博辉生物科技（广州）有限公司提供； *发表【英文论文】请标注：From Bohui Biological Technology (Guangzhou) Co., Ltd.
Cell Death Differ：中大五院黄曦团队发现新冠病毒引起肺损伤的分子机制
上皮细胞线粒体凋亡，并导致肺水肿的发生。 图片来源：Cell death & differentiation 病毒相关蛋白与细胞蛋白相互作用影响细胞凋亡过程。作者首先分别将携带刺突蛋白（Spike protein, S 蛋白），核衣壳蛋白（Nucleocapsid, N 蛋白），膜蛋白（Membrane protein, M 蛋白）和包膜蛋白（Envelope protein，E 蛋白）真核表达质粒载体分别转染人肺上皮 H292 细胞和人血管内皮 EA.hy926 细胞，通过荧光分光光度法检测胞内活化
Cell：「来骗来偷袭」剪接体靶向疗法「诱骗」机体，激活抗病毒免疫，让肿瘤自杀
传导以往研究表明，MYC 诱导的三阴性乳腺癌（triple-negative breast cancer，TNBC）对剪接体的基因扰动（genetic perturbation）很敏感，然而对剪接体抑制产生应答的途径仍然未知。基于此，作者首先对两个 MYC 诱导的 TNBC 细胞系 SUM159 和 LM2 的转录变化进行了表征，然后用小分子剪接体调节剂 SD6 进行处理。基因富集分析发现免疫信号通路（干扰素 α 和 β 信号通路）是正向富集最显著的途径，另外干扰素刺激基因 (如 OAS1、MX1
的形态和生理特性。最后，与传统的2D细胞培养条件相比，这些水凝胶允许对细胞进行包封，以实现细胞在更贴近天然组织环境的3D环境中进行生长。 TRUEGEL3D™的功能和优点 TrueGel3D™适用于多种细胞系（MDCK、上皮细胞、成纤维细胞、癌细胞、原代细胞（包括淋巴细胞）、基质和胚胎心肌细胞）。 TrueGel3D™中形成水凝胶骨架的基本成分（葡聚糖、PVA、PEG）不会干扰细胞行为 凝胶透明，支持细胞成像分析 基于不同的凝胶速度，多种TrueGel3D™试剂盒可供选，可支持多种应用
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