IOMM-Lee细胞

IOMM-Lee /IOMM-Lee 细胞系/IOMM-Lee 细胞株/IOMM-Lee 人脑膜瘤细胞

Cell line name IOMM-Lee

Synonyms IOMM-LEE; Iomm-Lee; IOMM Lee; IOMMLEE; IntraOsseous Malignant Meningioma-Lee

Accession CVCL_5779

Resource Identification Initiative To cite this cell line use: IOMM-Lee (RRID:CVCL_5779)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Population: Chinese.

Doubling time: ~62 hours (PubMed=2234331); 18 hours (PubMed=25984343); 0.8 day (PubMed=34850056); ~22 hours (ATCC=CRL-3370).

Omics: Array-based CGH.

Omics: Deep exome analysis.

Omics: shRNA library screening.

Derived from site: In situ; Brain; UBERON=UBERON_0000955.

Sequence variations

Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (DepMap=ACH-000629).

Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=28552950).

Disease Intracranial meningioma (NCIt: C4656)

Meningioma (ORDO: Orphanet_2495)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Children:

CVCL_HA67 (IOMM-Lee-LucNeo)

Sex of cell Male

Age at sampling 61Y

Category Cancer cell line

STR profile Source(s): ATCC=CRL-3370

 

Markers:

Amelogenin X

CSF1PO 9,10

D5S818 11,13

D7S820 11,12

D13S317 8,9

D16S539 12,13

TH01 6,7

TPOX 8,11

vWA 17,18

 

Run an STR similarity search on this cell line

Publications

PubMed=2234331; DOI=10.1097/00006123-199009000-00008

Lee W.-H.

Characterization of a newly established malignant meningioma cell line of the human brain: IOMM-Lee.

Neurosurgery 27:389-396(1990)

 

PubMed=16554968; DOI=10.1007/s11060-005-9076-y

Baia G.S., Slocum A.L., Hyer J.D., Misra A., Sehati N., VandenBerg S.R., Feuerstein B.G., Deen D.F., McDermott M.W., Lal A.

A genetic strategy to overcome the senescence of primary meningioma cell cultures.

J. Neurooncol. 78:113-121(2006)

 

PubMed=18261772; DOI=10.1016/j.surneu.2007.06.031

Ragel B.T., Couldwell W.T., Gillespie D.L., Wendland M.M., Whang K., Jensen R.L.

A comparison of the cell lines used in meningioma research.

Surg. Neurol. 70:295-307(2008)

 

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652

Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Sci. Data 1:140035-140035(2014)

 

PubMed=28552950; DOI=10.1371/journal.pone.0178322; PMCID=PMC5446134

Mei Y., Bi W.-Y.L., Greenwald N.F., Agar N.Y.R., Beroukhim R., Dunn G.P., Dunn I.F.

Genomic profile of human meningioma cell lines.

PLoS ONE 12:E0178322-E0178322(2017)

 

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)

 

PubMed=34850056; DOI=10.1093/jnen/nlab111; PMCID=PMC8716066

Uhlmann E.J., Rabinovsky R., Varma H., El Fatimy R., Kasper E.M., Moore J.M., Vega R.A., Thomas A.J., Alterman R.L., Stippler M., Anderson M.P., Uhlmann E.N., Kipper F.C., Krichevsky A.M.

Tumor-derived cell culture model for the investigation of meningioma biology.

J. Neuropathol. Exp. Neurol. 80:1117-1124(2021)