CFPAC-1细胞

CFPAC-1/CFPAC-1细胞系/CFPAC-1细胞株/CFPAC-1人胰腺导管癌细胞

Cell line name CFPAC-1

Synonyms CFPac-1; CF PAC-1; CF-PAC1; CF-Pac1; CF Pac1; CFPAC1; CFPac1; CFPAC

Accession CVCL_1119

Resource Identification Initiative To cite this cell line use: CFPAC-1 (RRID:CVCL_1119)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: KuDOS 95 cell line panel.

Part of: MD Anderson Cell Lines Project.

Part of: NCI RAS program mutant KRAS cell line panel.

Population: Caucasian.

Doubling time: 30 hours (Note=At 17th passage), 32 hours (Note=At 74th passage) (PubMed=1692630); 45 hours (PubMed=25984343); ~32 hours (ATCC=CRL-1918).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Metabolome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: Proteome analysis by 2D-DE/MS.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: CFPANC1; CGH-DB=164-1.

Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.

Source(s): ATCC=CRL-1918; CCRID; Cosmic-CLP=906821; PubMed=25877200

 

Markers:

Amelogenin X,Y

CSF1PO 10

D2S441 10,14

D2S1338 18,23

D3S1358 16

D5S818 10,11

D6S1043 20

D7S820 8,10

D8S1179 11,15

D12S391 17

D13S317 12

D16S539 9,11

D18S51 12

D19S433 13,15

D21S11 30,31.2

FGA 21,22

Penta D 11,13

Penta E 10,12

TH01 8

TPOX 8

vWA 17

PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721

Calhoun E.S., Hucl T., Gallmeier E., West K.M., Arking D.E., Maitra A., Iacobuzio-Donahue C.A., Chakravarti A., Hruban R.H., Kern S.E.

Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.

Cancer Res. 66:7920-7928(2006)

 

PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x; PMCID=PMC11158928

Suzuki A., Shibata T., Shimada Y., Murakami Y., Horii A., Shiratori K., Hirohashi S., Inazawa J., Imoto I.

Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.

Cancer Sci. 99:986-994(2008)

 

DOI=10.4172/jpb.1000057

Yamada M., Fujii K., Koyama K., Hirohashi S., Kondo T.

The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis.

J. Proteomics Bioinformatics 2:1-18(2009)

 

PubMed=19077451; DOI=10.1159/000178871

Harada T., Chelala C., Crnogorac-Jurcevic T., Lemoine N.R.

Genome-wide analysis of pancreatic cancer using microarray-based techniques.

Pancreatology 9:13-24(2009)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20418756; DOI=10.1097/MPA.0b013e3181c15963; PMCID=PMC2860631

Deer E.L., Gonzalez-Hernandez J., Coursen J.D., Shea J.E., Ngatia J., Scaife C.L., Firpo M.A., Mulvihill S.J.

Phenotype and genotype of pancreatic cancer cell lines.

Pancreas 39:425-435(2010)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)