SNF96.2细胞

SNF96.2细胞SNF96.2细胞SNF96.2;人雪旺细胞 (神经纤维瘤病Ⅰ型)

Cell line name sNF96.2

Synonyms SNF96.2; sNF96-2

Accession CVCL_K281

Resource Identification Initiative To cite this cell line use: sNF96.2 (RRID:CVCL_K281)

Comments Doubling time: ~33 hours (ATCC=CRL-2884).

Derived from site: In situ; Peripheral nervous system, lower leg nerve; UBERON=UBERON_0004218.

Cell type: Schwann cell; CL=CL_0002573.

Sequence variations

Mutation; HGNC; 7765; NF1; Simple; p.Asn1229Metfs*11 (c.3683delC); Zygosity=Hemizygous (PubMed=17876295).

Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)

Neurofibromatosis type 1 (NCIt: C3273)

Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)

Neurofibromatosis type 1 (ORDO: Orphanet_636)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell Male

Age at sampling 27Y

Category Cancer cell line

STR profile Source(s): ATCC=CRL-2884; PubMed=32076030

 

Markers:

Amelogenin X

CSF1PO 12

D2S1338 17

D3S1358 16 (ATCC=CRL-2884)

16,21 (PubMed=32076030)

D5S818 11

D7S820 10,11

D8S1179 13

D13S317 10

D16S539 11

D18S51 16

D19S433 13,14

D21S11 30

FGA 22

Penta D 14

Penta E 15

TH01 6

TPOX 11

vWA 17,19 (ATCC=CRL-2884)

17,19,20 (PubMed=32076030)

 

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Publications

PubMed=14762442; DOI=10.1038/sj.onc.1207068

Li Y.-W., Rao P.K., Wen R., Song Y., Muir D.F. 4th, Wallace P., van Horne S.J., Tennekoon G.I., Kadesch T.

Notch and Schwann cell transformation.

Oncogene 23:1146-1152(2004)

 

PubMed=17876295; DOI=10.1038/labinvest.3700675

Perrin G.Q., Li H., Fishbein L., Thomson S.A., Hwang M.S., Scarborough M.T., Yachnis A.T., Wallace M.R., Mareci T.H., Muir D.F. 4th

An orthotopic xenograft model of intraneural NF1 MPNST suggests a potential association between steroid hormones and tumor cell proliferation.

Lab. Invest. 87:1092-1102(2007)

 

PubMed=22346343; DOI=10.4137/TOG.S8830; PMCID=PMC3273949

Sun D., Tainsky M.A., Haddad R.

Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy.

Transl. Oncogenomics 5:1-7(2012)

 

PubMed=28469964; PMCID=PMC5411799

Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R., Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C., Field J.

Comprehensive pharmacological profiling of neurofibromatosis cell lines.

Am. J. Cancer Res. 7:923-934(2017)

 

PubMed=32076030; DOI=10.1038/s41598-020-59789-4; PMCID=PMC7031337

Amirnasr A., Verdijk R.M., van Kuijk P.F., Kartal P., Vriends A.L.M., French P.J., van Royen M.E., Taal W., Sleijfer S., Wiemer E.A.C.

Deregulated microRNAs in neurofibromatosis type 1 derived malignant peripheral nerve sheath tumors.

Sci. Rep. 10:2927-2927(2020)

 

PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054

Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.

Genetics of human malignant peripheral nerve sheath tumors.

Neurooncol. Adv. 2:i50-i61(2020)