DMS153细胞

DMS 153、DMS 153、DMS 153细胞、DMS 153细胞、DMS 153人小细胞肺癌细胞

Cell line name DMS 153

Synonyms DMS-153; DMS153; Darmouth Medical School 153

Accession CVCL_1175

Resource Identification Initiative To cite this cell line use: DMS 153 (RRID:CVCL_1175)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Population: Caucasian.

Doubling time: 28 days (PubMed=6266631); 5.8 days (PubMed=2986244).

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.

Sequence variations

Mutation; HGNC; 11998; TP53; Simple; p.Thr155Pro (c.463A>C); Zygosity=Homozygous (PubMed=14660794; DepMap=ACH-000594).

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0.64

Native American 0.56

East Asian, North 3.7

East Asian, South 0

South Asian 0

European, North 51.44

European, South 43.66

Disease Lung small cell carcinoma (NCIt: C4917)

Small cell lung cancer (ORDO: Orphanet_70573)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual CVCL_Z033 ! DMS 154

Sex of cell Male

Age at sampling 44Y

Category Cancer cell line

STR profile Source(s): ATCC=CRL-2064; CCRID; ECACC=95062827; PubMed=25877200

 

Markers:

Amelogenin X (ATCC=CRL-2064; CCRID)

X,Y (ECACC=95062827; PubMed=25877200)

CSF1PO 10

D2S1338 17,20

D3S1358 14,17 (PubMed=25877200)

17 (ATCC=CRL-2064; CCRID)

D5S818 12

D6S1043 11,18

D7S820 8,10

D8S1179 12,14

D13S317 12,13 (PubMed=25877200)

13 (ATCC=CRL-2064; CCRID; ECACC=95062827)

D16S539 12,13

D18S51 16,17

D19S433 12.1,15

D21S11 26.2,30

FGA 21

Penta D 9,12

Penta E 12 (ATCC=CRL-2064; CCRID)

12,13 (PubMed=25877200)

TH01 7,9.3

TPOX 11

vWA 14,15

 

Run an STR similarity search on this cell line

Publications

PubMed=6266631; DOI=10.1002/1097-0142(19800301)45:5<906::AID-CNCR2820450513>3.0.CO;2-H

Pettengill O.S., Sorenson G.D., Wurster-Hill D.H., Curphey T.J., Noll W.W., Cate C.C., Maurer L.H.

Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung.

Cancer 45:906-918(1980)

 

PubMed=2986244; DOI=10.1007/978-3-642-82372-5_5

Vindelov L.L., Hansen H.H., Spang-Thomsen M.

Growth characteristics and heterogeneity of small cell carcinoma of the lung.

Recent Results Cancer Res. 97:47-54(1985)

 

PubMed=9744504; DOI=10.1038/bjc.1998.553; PMCID=PMC2063065

Damstrup L., Voldborg B.G.R., Spang-Thomsen M., Brunner N., Poulsen H.S.

In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.

Br. J. Cancer 78:631-640(1998)

 

PubMed=12712436; DOI=10.1002/ijc.11106

Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.

The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.

Int. J. Cancer 105:472-479(2003)

 

PubMed=14660794; DOI=10.1073/pnas.2536558100; PMCID=PMC307654

Kanashiro C.A., Schally A.V., Groot K., Armatis P., Bernardino A.L.F., Varga J.L.

Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.

Proc. Natl. Acad. Sci. U.S.A. 100:15836-15841(2003)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922

Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F., Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Cancer Discov. 2:798-811(2012)

 

PubMed=25877200; DOI=10.1038/nature14397

Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.

A resource for cell line authentication, annotation and quality control.

Nature 520:307-311(2015)