CNE-2细胞

CNE-2细胞CNE-2人鼻咽癌细胞Synonyms CNE2

Accession CVCL_6889

Resource Identification Initiative To cite this cell line use: CNE-2 (RRID:CVCL_6889)

Comments Problematic cell line: Contaminated. On the basis of the STR profile (PubMed=18196576) it is identical to CNE-1 and seems to be a hybrid of HeLa and of cell line of unknown origin. Originally thought to originate from a 68 year old male patient with a nasopharyngeal carcinoma.

Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00474.

Omics: Transcriptome analysis by RNAseq.

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Parent: CVCL_0030 (HeLa)

Children:

CVCL_6890 (CNE-2Z) CVCL_C9B8 (CNE2-IR) CVCL_B0U9 (S18)

CVCL_B0UB (S26)

Category Hybrid cell line

STR profile Source(s): PubMed=18196576

 

Markers:

Amelogenin X

CSF1PO 10,11

D2S1338 17,23

D3S1358 15,18

D5S818 11,12

D7S820 10,12

D8S1179 12,17

D13S317 10,12,13.3

D16S539 9,10

D18S51 13,16

D19S433 13

D21S11 27,30

FGA 18,21

TH01 6,7,9

TPOX 8,9,12

vWA 14,16

Publications

CLPUB00143

Zhang S.-H., Gao X.-C., Zeng Y.

Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma.

Yi Chuan Xue Bao 10:498-503(1983)

 

PubMed=6852976; DOI=10.1002/ijc.2910310509

Zhang S.-H., Gao X.-K., Zeng Y.

Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma.

Int. J. Cancer 31:587-590(1983)

 

PubMed=17062557; DOI=10.1158/0008-5472.CAN-06-2977

Qian C.-N., Berghuis B., Tsarfaty G., Bruch M., Kort E.J., Ditlev J., Tsarfaty I., Hudson E., Jackson D.G., Petillo D., Chen J.-D., Resau J.H., Teh B.T.

Preparing the 'soil': the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells.

Cancer Res. 66:10365-10376(2006)

 

PubMed=18196576; DOI=10.1002/ijc.23374

Chan S.Y.-Y., Choy K.-W., Tsao S.-W., Tao Q., Tang T., Chung G.T.-Y., Lo K.-W.

Authentication of nasopharyngeal carcinoma tumor lines.

Int. J. Cancer 122:2169-2171(2008)

 

PubMed=20406978; DOI=10.1158/0008-5472.CAN-09-4099

Feng X.-P., Yi H., Li M.-Y., Li X.-H., Yi B., Zhang P.-F., Li C., Peng F., Tang C.-E., Li J.-L., Chen Z.-C., Xiao Z.-Q.

Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics.

Cancer Res. 70:3450-3462(2010)

 

PubMed=24991015; DOI=10.1128/JVI.01457-14; PMCID=PMC4178894

Strong M.J., Baddoo M., Nanbo A., Xu M., Puetter A., Lin Z.

Comprehensive high-throughput RNA sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes.

J. Virol. 88:10696-10704(2014)

 

PubMed=25028967; DOI=10.1371/journal.pone.0100843; PMCID=PMC4100732

Liang Y.-Y., Chen M.-Y., Hua Y.-J., Chen S., Zheng L.-S., Cao X., Peng L.-X., Xie P., Huang B.-J., Sun R., Wang L., Xiang Y.-Q., Guo X., Qian C.-N.

Downregulation of Ras association domain family member 6 (RASSF6) underlies the treatment resistance of highly metastatic nasopharyngeal carcinoma cells.

PLoS ONE 9:E100843-E100843(2014)

 

CLPUB00484

Xu Z.-H., Sun W.-W., Hang J.-B., Gao B.-L., Hu J.-A.

RNA-seq identified a novel functional MET fusion in head and neck cancer 5-8F cell line.

Int. J. Clin. Exp. Pathol. 9:8308-8317(2016)