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- Peprotech
- 200-10-50ug
- 2025年07月12日
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维百奥生物库存现货，特价销售Human IL-10 Recombinant Protein 50ug！
| 产品信息
品名：Human IL-10 Recombinant Protein
品牌：Peprotech
货号：200-10-50ug
规格：50ug
| 产品属性
| 种属 | Human | 形式 | Lyophilized |
| Expression System | E. coli | 纯化类型 | purified |
| 分子量 | 18.6 kDa | 内含物 | no preservative |
| 内毒素浓度 | <1 EU/µg | 保存条件 | -20°C |
| 偶联物 | Unconjugated | 运输条件 | Ambient |
| 已发表种属 | Human, Mouse, Non-human primate, Pig, Virus | ||
| 纯度 | ≥ 98% by SDS-PAGE gel and HPLC analyses. | ||
| 氨基酸序列 | MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N | ||
| 活性 | Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg. | ||
| 产品描述
Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues.
| 耙标信息
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Type 1.
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