- ￥4566
- 艾洛蒙
- ATN0018
- 苏州
- 2026年02月17日
- in vivo blocking of VEGF/VEGFR-2 signaling、 in vitro blocking of VEGFR signaling、 Western blot
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
InVivo Anti-mouse VEGFR-2 （DC101）
- 抗体英文名：
InVivo Anti-mouse VEGFR-2 （DC101）
- 靶点：
mouse VEGFR-2
- 浓度：
1mg/ml
- 应用范围：
in vivo blocking of VEGF/VEGFR-2 signaling、 in vitro blocking of VEGFR signaling、 Western blot
- 库存：
100
- 级别：
科研
- 克隆性：
单克隆
- 保存条件：
4°C保存
- 形态：
液体
- 亚型：
Rat IgG1
- 规格：
5mg
血管内皮生长因子受体（vascular endothelial growth factor receptor，VEGFR）是与血管内皮生长因子进行特异性结合的高亲和力受体，主要分为3类VEGFR-1、VEGFR-2、VEGFR-3，本质上都是酪氨酸蛋白激酶。VEGFR-1和VEGFR-2主要分布在血管内皮表面，调节血管的生成；VEGFR-3主要分布在淋巴内皮表面，调节淋巴管的生成。
VEGF对内皮细胞的增殖、分化作用是由VEGFR2介导的。
VEGFR2介导的信号转导途径有四个：
-
主要途径-MAPK途径（丝裂原活化蛋白激酶MAPK）；
-
PI3K-Akt/PKB途径；
-
Ca2+磷脂依赖性激酶途径；
-
FAK-Paxillin
The DC101 monoclonal antibody reacts with mouse VEGFR-2 (vascular endothelial growth factor receptor 2) also known as CD309, KDR, and Flk-1. VEGFR-2 is a member of the tyrosine protein kinase family. Upon binding to its ligand VEGF, VEGFR-2 pays key roles in vascular development and permeability. VEGFR-2 is expressed on endothelial cells at high levels in adult heart, lung, kidney, brain, and skeletal muscle as well as other tissues at lower levels. The DC101 antibody has been shown to inhibit VEGFR-2 signaling in vivo.
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文献和实验Low-Energy DC Current Ablation in a Mouse Tumor Model
Irreversible electroporation has recently been applied to tissue and tumor ablation. This animal model was developed to evaluate optimal parameters for subcutaneous tumor ablation. The immortalized Panc1 tumor cell line was used
to the development of tumours by their lack of appropriate function. As such, understanding human DC biology provides the insight needed to develop applications for their use in the treatment of diseases. Currently, studies on mouse DC outnumber those on human cells
monoclonal anti-HA 16B12 (MMS101R, BAbCo, used at 1:200 to 1:1000 dilution) mouse monoclonal anti-HA 12CA5 (12CA5, Boehringer, used at 1:200 dilution) rabbit polyclonal anti-HA (RS1010C, BAbCo, used at 1:200 dilution) Cy3-conjugated affinity
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