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- 碧云天（beyotime）
- S0024
- 2025年11月10日
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总一氧 化氮检测试剂盒(Total Nitric Oxide Assay Kit, 即Nitrate/Nitrite Assay Kit)采用了硝酸盐还原酶(Nitrate reductase)还原硝酸盐(nitrate)为亚硝酸盐(nitrite)，然后通过经典的Griess reagent检测亚硝酸盐， 从而测定出总一氧 化氮。一氧 化氮本身极不稳定，在细胞内很快代谢为硝酸盐(Nitrate)和亚硝酸盐(Nitrite)，通过上述方法检测出硝酸盐和亚硝酸盐的总量，就可以推算出总的一氧 化氮的量。
本试剂盒采用了NADPH依赖性硝酸盐还原酶(NADPH dependent nitrate reductase)。高浓度的NADPH会干扰后续的检测，消除NADPH的一种常用方法就是使用Lactate dehydrogenase(LDH)清除NADPH。本试剂盒采用了LDH清除NADPH的方法，使检测结果更加准确。
对亚硝酸盐的检测下限达到2微摩尔/升，在2-80微摩尔/升的范围内有很好的线性关系。浓度过高的样品可以适当稀释后再进行检测。
样品范围广，可以检测细胞裂解液、组织裂解液、细胞或组织的培养液、血清、血浆或尿液等中一氧 化氮的含量。酚红和10%血清对测定无 明显干扰。
样品需要量少。根据样品中一氧 化氮的浓度不同，仅需0-60微升样品。
检测速度快，仅需约80分钟即可完成检测。
本试剂盒采用了间接的一氧 化氮检测方法，如需检测细胞内实际的一氧 化氮水平，可以采用碧云天生产的DAF-FM DA(NO荧光探针)(S0019)。
包装清单：
| 产品编号 | 产品名称 | 包装 |
| S0024-1 | 样品稀释液 | 15ml |
| S0024-2 | NADPH | 5mg |
| S0024-3 | FAD | 1.1ml X2 |
| S0024-4 | Nitrate Reductase | 1ml |
| S0024-5 | LDH Buffer | 1.1ml X2 |
| S0024-6 | LDH | 1ml X2 |
| S0024-7 | NaNO2(1M) | 1ml |
| S0024-8 | Griess Reagent I | 12ml |
| S0024-9 | Griess Reagent II | 12ml |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，一年有效。NADPH，Nitrate Reductase，NaNO2 (1M)，Griess Reagent I和Griess Reagent II需避光保存。NADPH配制成溶液后必须分装并-70℃保存。
注意事项：
RPMI 1640等含有较高浓度硝酸盐的培养液容易对本试剂盒的检测产生干扰，请尽量避免。必需使用RPMI 1640培养液时，在检测一氧 化氮前必需先换成其他适当培养液例如DMEM、MEM、F12等，或换成HBSS或PBS等。
推荐选购碧云天生产的细胞与组织裂解液(一氧 化氮检测用)(S3090)用于细胞或组织样品的裂解。也可以自行选择适当方式制备细胞或组织样品的裂解液用于总一氧 化氮的检测，但需注意自行选择的方式可能会干扰试剂盒检测时的酶反应而影响检测效果。检测细胞或组织的培养液、血清、血浆或尿液中的总一氧 化氮含量时，不需要选购S3090。S3090裂解获得的样品还可以用于蛋白浓度的检测以及Western印迹检测，但需注意S3090中不含蛋白酶和磷酸酯酶抑制剂。
检测反应必须避光进行。
由于检测过程中有还原反应，凡是影响还原反应的氧化或还原试剂要注意避免，例如常用的还原剂DTT和巯基乙醇。
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70. Wei SJ, Cheng L, Liang ES, Wang Q, Zhou SN, Xu H, Hui LH, Ge ZM, Zhang MX.
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Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aorticatherogenesis through downregulation of arginase II.
CLIN EXP PHARMACOL P . 2017 Jan;44(1):114-122. (IF 2.092)
71. Liu C, Hao Y, Huang J, Li H, Yang Z, Zeng Y, Liu J, Li R.
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Ghrelin accelerates wound healing in combined radiation and wound injury in mice.
Exp Dermatol. 2017 Feb;26(2):186-193. (IF 3.368)
72. Guo J, Wang Y, Wang J, Zhang J, Fang J.
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Radiosensitization of oral tongue squamous cell carcinoma by nanosecond pulsed electric fields (nsPEFs).
Bioelectrochemistry. 2017 Feb;113:35-41. (IF 4.722)
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Ginsenoside Rb2 enhances the anti-inflammatory effect ofω-3 fatty acid in LPS-stimulatedRAW264.7 macrophages by upregulating GPR120 expression.
Acta Pharmacol Sin. 2017 Feb;38(2):192-200. (IF 5.064)
74. Li XH, Xue WL, Wang MJ, Zhou Y, Zhang CC, Sun C, Zhu L, Liang K, Chen Y, Tao BB, Tan B, Yu B, Zhu YC.
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H2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3pexpression.
SCI REP-UK. 2017 Mar 21;7:44807. (IF 3.998)
75. Chen XH, Liu SR, Peng B, Li D, Cheng ZX, Zhu JX, Zhang S, Peng YM, Li H, Zhang TT, Peng XX.
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Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens.
Front Immunol. 2017 Mar 6;8:207. (IF 5.085)
76. Ehsan M, Gao W, Gadahi JA, Lu M, Liu X, Wang Y, Yan R, Xu L, Song X, Li X.
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Arginine kinase from Haemonchus contortus decreased the proliferation and increased the apoptosis of goat PBMCs in vitro.
PARASITE VECTOR. 2017 Jun 26;10(1):311. (IF 2.824)
77. Qing L, Ariyadewa DK, Yi H, Wang Y, Zhou Q, Xu W.
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Skin Lesions in Swine with Decompression Sickness: Clinical Appearance and Pathogenesis.
Front Physiol. 2017 Jul 25;8:540. (IF 3.367)
78. Liu X, Ma Q, Sun X, Lu M, Ehsan M, Hasan MW, Xu L, Yan R, Song X, Li X.
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Front Microbiol. 2017 Jul 21;8:1376. (IF 4.235)
79. Chen P, Gao H, Lu Y, Nie H, Liu Z, Zhao Y, Fan N, Zou Q, Dai Y, Tang A, Hara H, Cai Z, Cooper DKC, Lai L, Mou L.
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Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase,and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation.
Cell Biol Int. 2017 Jul;41(7):798-808. (IF 2.571)
80. Jiang J, Gan Z, Li Y, Zhao W, Li H, Zheng JP, Ke Y.
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REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles ofthe eNOS/NO/cGMP pathway and supplementation with L-arginine.
PLoS One. 2017 Aug 15;12(8):e0182746. (IF 2.74)
81. Hou N, Jiang N, Zou Y, Piao X, Liu S, Li S, Chen Q.
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Front Microbiol. 2017 Aug 2;8:1431. (IF 4.235)
82. Lu M, Tian X, Yang X, Yuan C, Ehsan M, Liu X, Yan R, Xu L, Song X, Li X.
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TheN-and C-terminal carbohydrate recognition domains of Haemonchus contortus galectin bind to distinct receptors of goat PBMC and contribute differently to its immunomodulatory functions in host-parasite interactions.
PARASITE VECTOR. 2017 Sep 5;10(1):409. (IF 2.824)
83. Shang Q, Bao L, Guo H, Hao F, Luo Q, Chen J, Guo C.
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Transl Res. 2017 Oct;188:92-105. (IF 5.411)
84. Long Y, Huang C, Wu J, Cheng JN, Liang GN, Jiang CX, Wan Q.
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2,3',4,4',5-Pentachlorobiphenyl impairs insulin-induced NO production partly through excessiveROS production in endothelial cells.
TOXICOL MECH METHOD. 2017 Oct;27(8):592-597. (IF 2.295)
85. Gadahi JA, Ehsan M, Wang S, Zhang Z, Yan R, Song X, Xu L, Li X.
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Recombinant protein of Haemonchus contortus small GTPase ADP-ribosylation factor 1 (HcARF1) modulate the cell mediated immune response in vitro.
ONCOTARGET. 2017 Nov 26;8(68):112211-21. (IF 5.168)
86. Qiu Y, Sui X, Cao S, Li X, Ning Y, Wang S, Yin L, Zhi X.
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Steroidogenic Acute Regulatory Protein (StAR) Overexpression Reduces Inflammation and Insulin Resistance in Obese Mice.
J Cell Biochem. 2017 Nov;118(11):3932-3942. (IF 4.237)
87. Zheng Y, Wu Z, Yi F, Orange M, Yao M, Yang B, Liu J, Zhu H
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By Activating Akt/eNOS Bilobalide B Inhibits Autophagy and Promotes Angiogenesis Following Focal Cerebral Ischemia Reperfusion.
CELL PHYSIOL BIOCHEM. 2018;47(2):604-616. (IF 5.5)
88. Li H, Chen LP, Wang T, Wang SG, Liu JH.
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Calpain inhibition improves erectile function in diabetic mice via upregulating endothelial nitricoxide synthase expression and reducing apoptosis.
Asian J Androl. 2018 Jan 9. (IF 2.448)
89. Zhu BB, Wang H, Chi YF, Wang YM, Yao XM, Liu S, Qiu H, Fang J, Yin PH, Zhang XM, Peng W.
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Protective effects of probucol on Ox-LDL-induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells via LOX 1/ROS/MAPK signaling.
Mol Med Rep. 2018 Jan;17(1):1289-1296. (IF 2.1)
90. Mao J, Hu X, Pang P, Zhou B, Zhang Y, Li D, Shan H.
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PROTEOM CLIN APPL. 2018 Jan 26. (IF 2.489)
91. He SW, Wang GH, Yue B, Zhou S, Zhang M.
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TO17:A teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus.
FISH SHELLFISH IMMUN. 2018 Jan;72:639-645. (IF 3.298)
92. Ma LL, Li Y, Yin PP, Kong FJ, Guo JJ, Shi HT, Zhu JB, Zou YZ, Ge JB.
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Hypertrophied myocardium is vulnerable to ischemia/reperfusion injury and refractory to rapamycin-induced protection dueto increased oxidative/nitrative stress.
CLIN SCI. 2018 Jan 11;132(1):93-110. (IF 5.223)
93. Zhang B, Zhang Z, Ji H, Shi H, Chen S, Yan D, Jiang X, Shi B
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Grape seed proanthocyanidin extract alleviates urethral dysfunction in diabetic rats through modulating the NO-cGMP pathway.
Exp Ther Med. 2018 Jan;15(1):1053-1061. (IF 1.785)
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FISH SHELLFISH IMMUN. 2018 Jan;72:639-645. (IF 3.298)
95. Deng X, Huang W, Peng J, Zhu TT, Sun XL, Zhou XY, Yang H, Xiong JF, He HQ, Xu YH, He YZ.
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Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and EndothelialDysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling.
Inflammation. 2018 Feb;41(1):260-275. (IF 3.212)
96. Long Y, Chen SW, Gao CL, He XM, Liang GN, Wu J, Jiang CX, Liu X, Wang F, Chen F.
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ATP2B1 GeneSilencing Increases NO Production Under Basal Conditions ThroughtheCa2+/calmodulin/eNOS Signaling Pathway in Endothelial Cells.
Hypertens Res. 2018 Feb 7. (IF 2.941)
97. Deng X, Huang W, Peng J, Zhu TT, Sun XL, Zhou XY, Yang H, Xiong JF, He HQ, Xu YH, He YZ
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Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling.
Inflammation. 2018 Feb;41(1):260-275. (IF 3.212)
98. Ma LL, Ma X, Kong FJ, Guo JJ, Shi HT, Zhu JB, Zou YZ, Ge JB.
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Mammaliantargetofrapamycin inhibition attenuates myocardial ischaemia-reperfusion injury in hypertrophic heart.
J Cell Mol Med. 2018 Mar;22(3):1708-1719. (IF 4.486)
99. Pan P, Zhang H, Su L, Wang X, Liu D
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Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy.
Molecules. 2018 Mar 16;23(3). pii: E675. (IF 3.267)
100. Tian AL, Lu M, Calderón-Mantilla G, Petsalaki E, Dottorini T, Tian X, Wang Y, Huang SY, Hou JL, Li X, Elsheikha HM, Zhu XQ
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A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells.
PARASITE VECTOR. 2018 Mar 6;11(1):152. (IF 2.824)
101. Cui K, Tang Z, Li CC, Wang T, Rao K, Wang SG, Liu JH, Chen Z
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Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis.
Asian J Androl. 2018 Mar-Apr;20(2):166-172. (IF 2.448)
102. Ma LL, Ma X, Kong FJ, Guo JJ, Shi HT, Zhu JB, Zou YZ, Ge JB.
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Mammalian target of rapamycin inhibition attenuates myocardial ischaemia-reperfusion injury in hypertrophic heart.
J Cell Mol Med. 2018 Mar 22(3):1708-1719. (IF 4.486)
103. Zheng D, Cai A, Xu R, Mai Z, Zhou Y, Zeng F, Li L, Mai W
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Arch Med Sci. 2018 Apr;14(3):629-634. (IF 2.807)
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High molecular weight hyaluronan attenuates fine particulate matter-induced acute lung injury through inhibition of ROS-ASK1-p38/JNK-mediated epithelial apoptosis.
ENVIRON TOXICOL CHEM. 2018 Apr;59:190-198. (IF 3.152)
105. Long Y, Chen SW, Gao CL, He XM, Liang GN, Wu J, Jiang CX, Liu X, Wang F, Chen F
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ATP2B1 Gene Silencing Increases NO Production Under Basal Conditions Through the Ca2+/calmodulin/eNOS Signaling Pathway in Endothelial Cells.
Hypertens Res. 2018 Apr;41(4):246-252. (IF 2.941)
106. Peng Y, Hu K
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Mol Med Rep. 2018 Apr;17(4):6174-6184. (IF 2.1)
107. Liu S, Zhang C, Chao N, Lu J, Zhang Y
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Cloning, Characterization, and Functional Investigation of VaHAESA from Vitis amurensis Inoculated with Plasmopara viticola.
Int J Mol Sci. 2018 Apr 16;19(4). pii: E1204. (IF 4.556)
108. Mao J, Hu X, Pang P, Zhou B, Zhang Y, Li D, Shan H
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Establishment of a CRISPR/Cas9-Mediated Cysltr1 Knockout Mouse Model and iTRAQ-Based Proteomic Analysis.
PROTEOM CLIN APPL. 2018 May;12(3):e1700087. (IF 2.489)
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Nanosecond pulsed electric fields promoting the proliferation of porcine iliac endothelial cells: An in vitro study.
PLoS One. 2018 May 1;13(5):e0196688. (IF 2.74)
110. Ehsan M, Wang W, Gadahi JA, Hasan MW, Lu M, Wang Y, Liu X, Haseeb M, Yan R, Xu L, Song X, Li X
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The Serine/Threonine-Protein Phosphatase 1 From Haemonchus contortus Is Actively Involved in Suppressive Regulatory Roles on Immune Functions of Goat Peripheral Blood Mononuclear Cells.
Front Immunol. 2018 Jul 16;9:1627. (IF 5.085)
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Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
AGING-US. 2018 Jul 24;10(7):1722-1744. (IF 4.831)
112. Li H, Chen LP, Wang T, Wang SG, Liu JH
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Calpain inhibition improves erectile function in diabetic mice via upregulating endothelial nitric oxide synthase expression and reducing apoptosis.
Asian J Androl. 2018 Jul-Aug;20(4):342-348. (IF 2.448)
113. Ma Y, Tang T, Sheng L, Wang Z, Tao H, Zhang Q, Zhang Y, Qi Z
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Aloin suppresses lipopolysaccharide‑induced inflammation by inhibiting JAK1‑STAT1/3 activation and ROS production in RAW264.7 cells.
Int J Mol Med. 2018 Oct;42(4):1925-1934. (IF 3.098)
114. Zhang R, Ji J, Blaženović I, Pi F, Wang T, Zhang Y, Sun X
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TOXINS. 2018 Oct 29;10(11). pii: E441. (IF 3.531)
115. Zhang F, Zhang JG, Yang W, Xu P, Xiao YL, Zhang HT
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6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation.
Biomed Pharmacother. 2018 Nov;107:1523-1529. (IF 4.545)
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Nitric oxide functions in stromal cell-derived factor-1-induced cytoskeleton changes and the migration of Jurkat cells.
Oncol Lett. 2018 Nov;16(5):6685-6690. (IF 2.311)
117. Zhao Z, Zhang H, Wang M, Zhang C, Kuang P, Zhou Z, Zhang G, Wang Z, Zhang B, Shi X
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The ethanol extract of honeysuckle stem modulates the innate immunity of Chinese mitten crab Eriocheir sinensis against Aeromonas hydrophila.
FISH SHELLFISH IMMUN. 2018 Nov;82:304-311. (IF 3.298)
118. Liu X, Li X, Wang Q, Sun X, Lu M, Ehsan M, Xu L, Yan R, Song X, Li X
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Toxoplasma gondii Histone 4 Affects Some Functions of Murine Ana-1 Macrophages In Vitro.
J Eukaryot Microbiol. 2018 Nov;65(6):860-869. (IF 2.143)
119. Tian AL, Lu M, Zhang FK, Calderón-Mantilla G, Petsalaki E, Tian X, Wang W, Huang SY, Li X, Elsheikha HM, Zhu XQ
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The pervasive effects of recombinant Fasciola gigantica Ras-related protein Rab10 on the functions of goat peripheral blood mononuclear cells.
PARASITE VECTOR. 2018 Nov 6;11(1):579. (IF 2.824)
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17β-estradiol inhibits human umbilical vascular endothelial cell senescence by regulating autophagy via p53.
Exp Gerontol. 2018 Dec;114:57-66. (IF 3.376)
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ENVIRON SCI POLLUT R. 2018 Dec 25(36):36136-36146. (IF 3.056)
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Over-Expression of a Maize N-Acetylglutamate Kinase Gene (ZmNAGK) Improves Drought Tolerance in Tobacco.
Front Plant Sci. 2019 Jan 4;9:1902. (IF 4.402)
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FASEB J. 2019 Mar;33(3):3718-3730. (IF 4.966)
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FISH SHELLFISH IMMUN. 2019 Mar 86:116-124. (IF 3.298)
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Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism.
VASC PHARMACOL. 2019 Apr;115:55-63. (IF 4.152)
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FISH SHELLFISH IMMUN. 2019 May 88:480-488. (IF 3.298)
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Vascular endothelial growth factor-modified macrophages accelerate reendothelialization and attenuate neointima formation after arterial injury in atherosclerosis-prone mice.
J Cell Biochem. 2019 Jun 120(6):10652-10661. (IF 4.237)
128. Wang Z, Song P, Li Y, Wang S, Fan J, Zhang X, Luan J, Chen W, Wang Y, Liu P, Ju D
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Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy.
APPL MICROBIOL BIOT. 2019 Jun 103(12):4825-4838. (IF 3.53)
129. Chang L, Wang Z, Ma F, Tran B, Zhong R, Xiong Y, Dai T, Wu J, Xin X, Guo W, Xie Y, Mao Y, Zhu YZ
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ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway.
Oxid Med Cell Longev. 2019 Jun 2 2019:6173685. (IF 5.076)
130. Hao H, Tian W, Pan C, Jiao Y, Deng X, Fan J, Han J, Han S, Wang M, Li P
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Marsdenia tenacissima extract dilated small mesenteric arteries via stimulating endothelial nitric oxide synthase and inhibiting calcium influx.
J Ethnopharmacol. 2019 Jun 28 238:111847. (IF 3.69)
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Metallomics. 2019 Jul 17 11(7):1277-1287. (IF 3.796)
132. Chen D, Tian AL, Hou JL, Li JX, Tian X, Yuan XD, Li X, Elsheikha HM, Zhu XQ
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The Multitasking Fasciola gigantica Cathepsin B Interferes With Various Functions of Goat Peripheral Blood Mononuclear Cells in vitro.
Front Immunol. 2019 Jul 23 10:1707. (IF 5.085)
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Adiponectin inhibits proliferation of vascular endothelial cells induced by Ox-LDL by promoting dephosphorylation of Caveolin-1 and depolymerization of eNOS and up-regulating release of NO.
Int Immunopharmacol. 2019 Aug 73:424-434. (IF 3.943)
134. Liu C, Wu QQ, Cai ZL, Xie SY, Duan MX, Xie QW, Yuan Y, Deng W, Tang QZ
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J Cell Mol Med. 2019 Sep 23(9):6466-6478. (IF 4.486)
135. Zhang J, Zhang SD, Wang P, Guo N, Wang W, Yao LP, Yang Q, Efferth T, Jiao J, Fu YJ
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Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells.
Eur J Pharmacol. 2019 Oct 15 861:172618. (IF 3.263)
136. Liu Y, Ye X, Li Y, Chu Q, Yu L, Chen W, Jia R, Jiang Y, Zheng X
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Food Sci Nutr. 2019 Oct 21 7(11):3644-3653. (IF 1.797)
137. Deng CK, Mu ZH, Miao YH, Liu YD, Zhou L, Huang YJ, Zhang F, Wang YY, Yang ZH, Qian ZY, Wang X, Guo JZ, Zhang MY, Liao XY, Wan Q, Lu D, Zou YY
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Gastrodin Ameliorates Motor Learning Deficits Through Preserving Cerebellar Long-Term Depression Pathways in Diabetic Rats.
FRONT NEUROSCI-SWITZ. 2019 Nov 22 13:1239. (IF 3.707)
138. Wang X, Chen S, Ren H, Chen J, Li J, Wang Y, Hua Y, Wang X, Huang N
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J Cell Mol Med. 2019 Dec 23(12):7985-7998. (IF 4.486)
140. Yang RH, Tan X, Ge LJ, Sun JC, Peng XD, Wang WZ
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NITRIC OXIDE-BIOL CH. 2019 Dec 1 93:44-52. (IF 3.311)
141. Qing Zhou, Qi Run, Chen-Yu Li, Xiang-Yu Xiong, Xiao-Lin Wu
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Cytogenet Genome Res. 2020;160(10):565-578. doi: 10.1159/000509811. (IF 1.114)
142. Xiuxiang Liu, Jinjin Wu, Chenying Zhu, Jie Liu, Xiaoli Chen, Tao Zhuang, Yashu Kuang, Yanfang Wang, Hao Hu, Ping Yu, Huimin Fan, Yuzhen Zhang, Zhongmin Liu, Lin Zhang
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Endothelial S1pr1 regulates pressure overload-induced cardiac remodelling through AKT-eNOS pathway
J Cell Mol Med. 2020 Jan;24(2):2013-2026. doi: 10.1111/jcmm.14900. (IF 4.486)
143. Pan Huang, Xuefei Shao, Miaomiao Zhu, Baocai Xu, Conggui Chen, Peijun Li
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Int J Food Microbiol. 2020 Feb 16;315:108419. doi: 10.1016/j.ijfoodmicro.2019.108419. (IF 4.187)
144. Zheng Y, Liu Z, Wang L, Li M, Zhang Y, Zong Y, Li Y, Song L
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FISH SHELLFISH IMMUN. 2020 Mar 98:334-341. (IF 3.298)
145. Lu H, Sun L, Chen W, Zhou Y, Liu K, Chen J, Zhang Z, Zhang C, Tian H
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Sirtuin 3 Therapy Attenuates Aging Expression, Oxidative Stress Parameters, and Neointimal Hyperplasia Formation in Vein Grafts.
Ann Vasc Surg. 2020 Apr 64:303-317. (IF 1.125)
146. Yujie Wei, Dongdong Lin, Zhanning Xu, Xiaoman Gao, Chaoshu Zeng, Haihui Ye
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A Possible Role of Crustacean Cardioactive Peptide in Regulating Immune Response in Hepatopancreas of Mud Crab
Front Immunol. 2020 Apr 30;11:711. doi: 10.3389/fimmu.2020.00711. (IF 5.085)
147. Pengwei Luan, Jiazhen Xu, Xinyue Ding, Qianfei Cui, Lixian Jiang, Yulan Xu, Yuying Zhu, Ruixiang Li, Guoqiang Lin, Ping Tian, Jiange Zhang
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Eur J Pharmacol. 2020 Apr 5;872:172944. doi: 10.1016/j.ejphar.2020.172944. (IF 3.263)
148. Jiaming Wang, Zhou Zhou, Dongmei Dan, Guoyuan Hu
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Int J Biol Macromol. 2020 May 1;150:573-577. doi: 10.1016/j.ijbiomac.2020.02.099. (IF 5.162)
149. Ping Gan, Lidong Ding, Guihua Hang, Qiaofang Xia, Zhimei Huang, Xing Ye, Xiaojuan Qian
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Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease
Front Pharmacol. 2020 May 26;11:776. doi: 10.3389/fphar.2020.00776. (IF 4.225)
150. Yan Dai, Jun Zhang, Rong Liu, Na Xu, Song-Biao Yan, Yi Chen, Tian-He Li
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The role and mechanism of asymmetric dimethylarginine in fetal growth restriction via interference with endothelial function and angiogenesis
J Assist Reprod Genet. 2020 May;37(5):1083-1095. doi: 10.1007/s10815-020-01750-5.
151. Qingbo Lv, Yao Wang, Ya Li, Liding Zhao, Yingchao Gong, Meihui Wang, Min Wang, Guosheng Fu, Wenbin Zhang
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Rosuvastatin Reverses Hypertension-Induced Changes in the Aorta Structure and Endothelium-Dependent Relaxation in Rats Through Suppression of Apoptosis and Inflammation
J Cardiovasc Pharmacol. 2020 Jun;75(6):584-595. doi: 10.1097/FJC.0000000000000828.
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Ionizing radiation induces BH 4 deficiency by downregulating GTP-cyclohydrolase 1, a novel target for preventing and treating radiation enteritis
Biochem Pharmacol. 2020 Oct;180:114102. doi: 10.1016/j.bcp.2020.114102. (IF 4.96)
153. Feng Zhou, Zhizhen Liu, Huazhong Cai, Zhenjun Miao, Faxing Wei, Chao Song
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Exp Ther Med. 2020 Nov;20(5):2. doi: 10.3892/etm.2020.9130. (IF 1.785)
154. Jingyu Song, Taotao Sun, Zhe Tang, Yajun Ruan, Kang Liu, Ke Rao, Ruzhu Lan, Shaogang Wang, Tao Wang, Jihong Liu
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Exosomes derived from smooth muscle cells ameliorate diabetes-induced erectile dysfunction by inhibiting fibrosis and modulating the NO/cGMP pathway
J Cell Mol Med. 2020 Nov;24(22):13289-13302. doi: 10.1111/jcmm.15946. (IF 4.486)
155. Xiaomin Su, Qianjing Zhang, Jianmei Yue, Yachen Wang, Yuan Zhang, Rongcun Yang
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Surface-layer protein produced by Lactobacillus crispatus JCM 2009 ameliorates lipopolysaccharide-induced inflammation through autophagy cross-talk with the NF-κB signaling pathway
Int J Biol Macromol. 2021 Jan 1;166:633-640. doi: 10.1016/j.ijbiomac.2020.10.221. (IF 5.162)
157. Jingya Wang, Lin Yao, Xiaoli Wu, Qi Guo, Shengxuan Sun, Jie Li, Guoqi Shi, Ruth B Caldwell, R William Caldwell, Yongjun Chen
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Protection against Doxorubicin-Induced Cardiotoxicity through Modulating iNOS/ARG 2 Balance by Electroacupuncture at PC6
Oxid Med Cell Longev. 2021 Mar 20;2021:6628957. doi: 10.1155/2021/6628957. (IF 5.076)
158. Xiyang Yang, Xingbing Li, Minghao Luo, Yongzheng Guo, Chang Li, Dingyi Lv, Zhe Cheng, Longxiang Huang, Fei-Fei Shang, Bi Huang, Jian Shen, Suxin Luo, Jianghong Yan
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Tubeimoside I promotes angiogenesis via activation of eNOS-VEGF signaling pathway
J Ethnopharmacol. 2021 Mar 1;267:113642. doi: 10.1016/j.jep.2020.113642. (IF 3.69)
159. Zhengqing Yu, Yujia Lu, Zhaoyi Liu, Muhammad Tahir Aleem, Junlong Liu, Jianxun Luo, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li
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Recombinant Toxoplasma gondii Ribosomal Protein P2 Modulates the Functions of Murine Macrophages In Vitro and Provides Immunity against Acute Toxoplasmosis In Vivo
Vaccines (Basel). 2021 Apr 7;9(4):357. doi: 10.3390/vaccines9040357.
160. Wenhua Lei, Junli Li, Changming Li, Li Chen, Fangyang Huang, Dan Xiao, Jialiang Zhang, Jiahao Zhao, Guoyong Li, Tianyi Qu, Hao Zhou, Yanbiao Liao, Mao Chen
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MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway
J Cell Mol Med. 2021 Apr;25(7):3182-3193. doi: 10.1111/jcmm.16386. (IF 4.486)
161. Huimin Lai, Zhengbiao Yang, Zhaohuan Lou, Feng Li, Feng Xie, Wei Pan, Cong Xu, Lili Zhang, Sheng Zhang, Lijiang Zhang, Mincong Huang
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Root Extract of Lindera aggregata (Sims) Kosterm. Modulates the Th17/Treg Balance to Attenuate DSS-Induced Colitis in Mice by IL-6/STAT3 Signaling Pathway
Front Pharmacol. 2021 May 13;12:615506. doi: 10.3389/fphar.2021.615506. (IF 4.225)
162. Wenxiang Mi, Shichong Qiao, Xiaomeng Zhang, Dongle Wu, Linyi Zhou, Hongchang Lai
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PRMT5 inhibition modulates murine dendritic cells activation by inhibiting the metabolism switch: a new therapeutic target in periodontitis
Ann Transl Med. 2021 May;9(9):755. doi: 10.21037/atm-20-7362. (IF 3.297)
163. Li-Ting Chen, Ting-Ting Xu, Ya-Qing Qiu, Nuo-Ya Liu, Xin-Yu Ke, Lu Fang, Jie-Ping Yan, Dan-Yan Zhu
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J Biochem Mol Toxicol. 2021 May;35(5):e22737. doi: 10.1002/jbt.22737.
164. Jia-Cen Sun, Xing Tan, Lian-Jie Ge, Ming-Juan Xu, Wei-Zhong Wang
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The Release of Nitric Oxide Is Involved in the β-Arrestin1-Induced Antihypertensive Effect in the Rostral Ventrolateral Medulla
Front Physiol. 2021 Jun 18;12:694135. doi: 10.3389/fphys.2021.694135. (IF 3.367)
165. Prince Last Mudenda Zilundu, Xiaoying Xu, Zaara Liaquat, Yaqiong Wang, Ke Zhong, Rao Fu, Lihua Zhou
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Long-Term Suppression of c-Jun and nNOS Preserves Ultrastructural Features of Lower Motor Neurons and Forelimb Function after Brachial Plexus Roots Avulsion
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166. Weiqing Jiang, Chen Liu, Mingzhu Deng, Fei Wang, Xiao Ren, Yilin Fan, Jiulin Du, Yonggang Wang
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H2S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish
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167. Miaoxuan Sun, Yi Sheng, Yanyan Zhu
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Ginkgolide B alleviates the inflammatory response and attenuates the activation of LPS-induced BV2 cells in vitro and in vivo
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168. Xiao-Xue Liang, Rui-Yu Wang, Yong-Zheng Guo, Zhe Cheng, Ding-Yi Lv, Ming-Hao Luo, An He, Su-Xin Luo, Yong Xia
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169. Zhanning Xu, Yujie Wei, Guizhong Wang, Haihui Ye
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B-type allatostatin regulates immune response of hemocytes in mud crab Scylla paramamosain
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170. Changliang Huo, Li Wang, Qiuli Wang, Yanbo Yang, Bo Chen
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Hydroxysafflor Yellow A inhibits the viability and migration of vascular smooth muscle cells induced by serum from rats with chronic renal failure via inactivation of the PI3K/Akt signaling pathway
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171. Hao Li, Wenchao Xu, Xiaming Liu, Tao Wang, Shaogang Wang, Jihong Liu, Hongyang Jiang
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JAK2 deficiency improves erectile function in diabetic mice through attenuation of oxidative stress, apoptosis, and fibrosis
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172. Zhen-Jie Wang, Shao-Meng Yu, Jiang-Mei Gao, Peng Zhang, Geoff Hide, Masahiro Yamamoto, De-Hua Lai, Zhao-Rong Lun
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173. HongYu Li, LanLan Yang, Ying Jin, ChunXiang Jin
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174. Qihong Zhang, Tingting Xie, Guodong Mo, Zihao Zhang, Ling Lin, Xiquan Zhang
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ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway
Front Immunol. 2021 Oct 29;12:774323. doi: 10.3389/fimmu.2021.774323. (IF 5.085)
175. Hui-Hui Zhou, Ye-Ming Zhang, Sheng-Peng Zhang, Qi-Xiang Xu, Ya-Qing Tian, Ping Li, Di Cao, Yong-Qiu Zheng
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Suppression of PTRF Alleviates Post-Infectious Irritable Bowel Syndrome via Downregulation of the TLR4 Pathway in Rats
Front Pharmacol. 2021 Oct 7;12:724410. doi: 10.3389/fphar.2021.724410. (IF 4.225)
176. Sen Yang, Xueni Zheng, Meng Qian, He Wang, Fei Wang, Yongzhen Wei, Adam C Midgley, Ju He, Hongyan Tian, Qiang Zhao
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Nitrate-Functionalized poly(ε-Caprolactone) Small-Diameter Vascular Grafts Enhance Vascular Regeneration via Sustained Release of Nitric Oxide
Front Bioeng Biotechnol. 2021 Nov 30;9:770121. doi: 10.3389/fbioe.2021.770121.
177. Yanwen Zhang, Yu Yao, Songyang Liu, Yufeng Chen, Shaohong Zhou, Kemin Wang, Xiaohai Yang, Jianbo Liu
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Coacervate microdroplet protocell-mediated gene transfection for nitric oxide production and induction of cell apoptosis
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178. Yunxin Zhang, Jianlong Liu, Wei Jia, Xuan Tian, Peng Jiang, Zhiyuan Cheng, Jinyong Li
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AGEs/RAGE blockade downregulates Endothenin-1 (ET-1), mitigating Human Umbilical Vein Endothelial Cells (HUVEC) injury in deep vein thrombosis (DVT)
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179. Lixian Huang, Bo Zhao, Qunxian Li, Jing Wu, Hui Jiang, Qingbin Li
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180. Yunxing Fu, Zhen Yang, Hongjuan Zhang, Yu Liu, Baocheng Hao, Ruofeng Shang
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14-O-[(4,6-Diamino-pyrimidine-2-yl) thioacetyl] mutilin inhibits α-hemolysin and protects Raw264.7 cells from injury induced by methicillin-resistant S. aureus
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181. Jingli Zhang, Lixia Liu
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Anagliptin alleviates lipopolysaccharide-induced inflammation, apoptosis and endothelial dysfunction of lung microvascular endothelial cells
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182. Tao Liu, Guowei Li, Xidong Wu, Shaohua Chen, Siyi Zhang, Hong Han, Hongbin Zhang, Xiaoning Luo, Xiang Cai, Dong Ma
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183. Lei-Lei Ma, Fei-Juan Kong, Yuan-Ji Ma, Jun-Jie Guo, Shi-Jun Wang, Zheng Dong, Ai-Jun Sun, Yun-Zeng Zou, Jun-Bo Ge
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Hypertrophic preconditioning attenuates post-myocardial infarction injury through deacetylation of isocitrate dehydrogenase 2
Acta Pharmacol Sin. 2021 Dec;42(12):2004-2015. doi: 10.1038/s41401-021-00699-0. (IF 5.064)
184. Qian Nie, Miaomiao Liu, Zhimei Zhang, Xuemei Zhang, Chao Wang, Guangyao Song
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185. Qing Gao, Tao Yang, Xin-Xin Li, Jun-Wei Xiong, Wei Ma, Yan-Min Xu, Yong Liu, Hong-Yan Zhang, Qi-Yu Wang, Hong-Xuan Wang, Ying Peng, Xiao-Feng Zhu, Yan-Zhong Guan
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Nitric Oxide Signaling Pathway in Ventral Tegmental Area is Involved in Regulation of 7,8-Dihydroxyflavone on Alcohol Consumption in Rats
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186. Jingjing Wu, Dongmei Zhang, Linlin Hu, Xiaowei Zheng, Caihong Chen
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Paeoniflorin alleviates NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 (SIRT1) to reduce H2O2-induced endoth
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187. Guoping Mao, Dedong Xin, Qian Wang, Dongmei Lai
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Sodium molybdate inhibits the growth of ovarian cancer cells via inducing both ferroptosis and apoptosis
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188. Kai Zhang, Xia Xu, Lihong Hu
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Sevoflurane attenuates hepatic ischemia reperfusion injury by the miR-122/Nrf2 pathway
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189. Yang Zhu, Jingya Wang, Lin Yao, Yunxuan Huang, Haitao Yang, Xiaojiang Yu, Xinghua Chen, Yongjun Chen
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Electroacupuncture at BL15 attenuates chronic fatigue syndrome by downregulating iNOS/NO signaling in C57BL/6 mice
Anat Rec (Hoboken). 2022 May 24. doi: 10.1002/ar.24953.
190. Xiancui Zhang, Huihui Feng, Jintao He, Xili Liang, Nan Zhang, Yongqi Shao, Fan Zhang, Xingmeng Lu
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The gut commensal bacterium Enterococcus faecalis LX10 contributes to defending against Nosema bombycis infection in Bombyx mori
Pest Manag Sci. 2022 Jun;78(6):2215-2227. doi: 10.1002/ps.6846. (IF 3.75)
191. Yun He, Hongyu Su, Na Li, Yingying Zhang, Pengjie Zhang, Yumeng Zhang, Yang Ye, Yueming Zhang, Jiaqi Tang, Zhice Xu
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In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: role of ROS/ERK1/2
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192. Wei Mu, Na Hu, Lan-Hui Zhang, Wei Jiang, Tao Yan, Tian Zhang, An Liu, Yong-Qiang Zhang, Jun Zhao, Lei Shi, Lin-Na Liu
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Lonicerae japonicae flos ameliorates radiotherapy-induced mesenteric artery endothelial dysfunction through GTPCH1/BH4/eNOS pathway
Phytomedicine. 2022 Jul 20:102:154146. doi: 10.1016/j.phymed.2022.154146. (IF 4.268)
193. Jiaxin Wang, Jingyu Song, Guoda Song, Yuhong Feng, Jiancheng Pan, Xiaoqing Yang, Zhongcheng Xin, Peng Hu, Taotao Sun, Kang Liu, Wenchao Xu, Tao Wang, Shaogang Wang, Jihong Liu, Yajun Ruan
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Acetyl-L-carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration
Andrology. 2022 Jul;10(5):984-996. doi: 10.1111/andr.13187. (IF 2.86)
194. Zhihui Fu, Xiaohui Wang, Xuan Lu, Ying Yang, Lingling Zhao, Lin Zhou, Kaikai Wang, Hanlin Fu
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Mannose-decorated ginsenoside Rb1 albumin nanoparticles for targeted anti-inflammatory therapy
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195. Xiaohan Xu, Zhiqiang Tian, Anqi Xing, Zichen Wu, Xuyan Li, Lingcong Dai, Yiyang Yang, Juan Yin, Yuhua Wang
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Nitric Oxide Participates in Aluminum-Stress-Induced Pollen Tube Growth Inhibition in Tea ( Camelliasinensis) by Regulating CsALMTs
Plants (Basel). 2022 Aug 29;11(17):2233. doi: 10.3390/plants11172233.
196. Huan Feng, Qi Liu, Zhiyao Deng, Hao Li, Huajie Zhang, Jingyu Song, Xiaming Liu, Jihong Liu, Bo Wen, Tao Wang
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Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis
Stem Cell Res Ther. 2022 Sep 5;13(1):450. doi: 10.1186/s13287-022-03147-w. (IF 5.116)
197. Liang-Liang Tang, Xu Yang, Shu-Qi Yu, Qi Qin, Rong Xue, Yu Sun, Han Xiao, An-Qi Shang, Jia-Qun Liu, Song-Qi Han, Chen Liang, Jie Lou, Qiu-Shi Wang, Chang-Jiang Yu, Ming-Ming Wu, Zhi-Ren Zhang
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Aldosterone-stimulated endothelial epithelial sodium channel (EnNaC) plays a role in cold exposure-induced hypertension in rats
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198. Lu Feng, Zhengmeng Yang, Yucong Li, Nan Hou, Boguang Yang, Xuan Lu, Shanshan Bai, Ming Wang, Xiaoting Zhang, Haixing Wang, Yaofeng Wang, Micky D Tortorella, Gang Li
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Malat1 attenuated the rescuing effects of docosahexaenoic acid on osteoarthritis treatment via repressing its chondroprotective and chondrogenesis activities
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199. Sheng-Qing Gao, Jia-Jun Shi, Xue-Wang, Shu-Hao Miao, Tao Li, Chao-Chao Gao, Yan-Ling Han, Jia-Yin Qiu, Yun-Song Zhuang, Meng-Liang Zhou
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Endothelial NOX4 aggravates eNOS uncoupling by decreasing dihydrofolate reductase after subarachnoid hemorrhage
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Targeted delivery of liver X receptor agonist to inhibit neointimal hyperplasia by differentially regulating cell behaviors
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201. Xing Tan, Peng Ye, Wan-Yang Li, Yuan Gao, Yue-Qi Leng, Wei Duan, Yang-Kai Wang, Wei-Zhong Wang
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The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the
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202. Bingliang Lian, Jingwen Gu, Chen Zhang, Zhicong Zou, Meng Yu, Fanghong Li, Xiaoli Wu, Allan Zijian Zhao
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Protective effects of isofraxidin against scopolamine-induced cognitive and memory impairments in mice involve modulation of the BDNF-CREB-ERK signaling pathway
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203. Ping Xu, Xiaobo Xu, Hanna Fotina, Tetiana Fotina
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Anti-inflammatory effects of chlorogenic acid from Taraxacum officinale on LTA-stimulated bovine mammary epithelial cells via the TLR2/NF-κB pathway
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