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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
HCT-116
- 库存：
99
- 供应商：
上海富衡生物科技有限公司
- 肿瘤类型：
属于结肠癌
- 细胞类型：
属于恶性上皮源性肿瘤细胞
- 品系：
优级品
- 组织来源：
来自结肠的上皮组织
- 相关疾病：
主要与结肠癌相关
- 物种来源：
人源
- 免疫类型：
/
- 细胞形态：
呈上皮样细胞形态，贴壁生长时多为多边形或梭形，细胞边界相对清晰，细胞核较大，核仁明显，细胞质丰富
- 是否是肿瘤细胞：
是
- 器官来源：
源于人体的结肠器官
- 运输方式：
常温运输
- 年限：
数年
- 生长状态：
贴壁生长
- 规格：
1×10⁶cells/T25培养瓶
| 产品名称 | 人结肠癌细胞；HCT-116 (STR) |
|---|---|
| 品牌 | FuHeng |
| 英文名 | HCT-116 (STR) |
| 货号 | FH0027 |
| 规格 | 1×10⁶cells/T25培养瓶 |
| 培养 | McCOY's5A+10%FBS |
| 别称 | HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 |
| 形态特征 | 上皮样 |
| 生长特性 | 贴壁生长 |
| 培养基 | HCT-116完全培养基 |
| 培养条件 | 气相：空气，95%；CO2,5%温度：37℃ |
| 传代方法 | 1:3传代，3-4天换液一次 |
| 组织来源 | 结肠癌组织 |
| 细胞简介 | 该细胞系分离自一名50 岁男性患者的结肠腺癌（原发灶，未转移），属于腺癌类型，是研究结直肠癌分子机制及药物开发的经典模型。 |
| 特征特性 | HCT116是1979年M.Brattain等从患结肠癌的男性病人中分离的三株恶性细胞之一。在半固体琼脂糖培养基中形成克隆。HCT116在无胸腺的裸鼠有致瘤性，形成上皮样的肿瘤 |
| 特别声明 | 富衡细胞库承诺尽最大努力对实验细胞资源相关信息进行及时更新。但限于当时的技术条件，细胞库资料不保证其准确性。 |
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文献和实验The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice (Retracted Article)
时间：2022-6-10
作者：Jiafei Wu;Decai Tang
杂志：GASTROENTEROLOGY RESEARCH AND PRACTICE
DOI：10.1155/2022/9578307
IF：2
Nanobody-Engineered Biohybrid Bacteria Targeting Gastrointestinal Cancers Induce Robust STING-Mediated Anti-Tumor Immunity
时间：2024-6-18
作者：Xiaolong Xu;Youbin Ding;Yafang Dong;Haitao Yuan;Peng Xia;Chengming Qu;Jingbo Ma;Huifang Wang;Xiaodong Zhang;Liang Zhao;Zhijie Li;Zhen Liang;Jigang Wang
杂志：ADVANCED SCIENCE
DOI：10.1002/advs.202401905
IF：14.3
Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-KB and Ras/Raf/MEK pathways
时间：2021-6-12
作者：Xueshuang Liu;Yue Xing;Mingyue Li;Zhihong Zhang;Jingying Wang;MyongHak Ri;Chenghua Jin;Guanghua Xu;Lianxun Piao;Honglan Jin;Hongxiang Zuo;Juan Ma;Xuejun Jin
杂志：JOURNAL OF ETHNOPHARMACOLOGY
DOI：10.1016/j.jep.2021.113989
IF：4.8
Integrative analysis of single-cell and bulk RNA seq to reveal the prognostic model and tumor microenvironment remodeling mechanisms of cuproptosis-related genes in colorectal cancer
时间：2023-12-15
作者：Bowen Chu;Yaohui Wang;Jiwen Yang;Bohan Dong
杂志：AGING-US
DOI：10.18632/aging.205324
IF：3.9
Identification of EGR4 as a prospective target for inhibiting tumor cell proliferation and a novel biomarker in colorectal cancer
时间：2024-6-1
作者：Bangting Wang;Shijie Zhang;Haiyang Wang;Min Wang;Yuwen Tao;Mujie Ye;Zhining Fan;Yan Wang;Li Liu
杂志：CANCER GENE THERAPY
DOI：10.1038/s41417-024-00743-1
IF：4.8
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway
时间：2020-6-6
作者：Shuo Ren; Yanwei Xing; Chengbo Wang; Fengqi Jiang; Guangyu Liu; Ziyi Li; Tao Jiang; Yuekun Zhu; Daxun Piao
杂志：The International Journal of Biochemistry & Cell Biology
DOI：10.1016/j.biocel.2020.105777
IF：3.4
Creatine kinase mitochondrial 2 promotes the growth and progression of colorectal cancer via enhancing Warburg effect through lactate dehydrogenase B
时间：2024-6-28
作者：Shasha Cai;Qingqing Xia;Darong Duan;Junhui Fu;Zhenxing Wu;Zaixing Yang;Changfa Yu
杂志：PEERJ
DOI：10.7717/peerj.17672
IF：2.3
CircVMP1 promotes glycolysis and disease progression by upregulating HKDC1 in colorectal cancer
时间：2024-3-1
作者：HongYu Chen;XiangNan Li;Lei Yang;ChunXiang Ye;ZhiLei Chen;ZhenJun Wang
杂志：ENVIRONMENTAL TOXICOLOGY
DOI：10.1002/tox.24061
IF：4.4
Bismuth oxide nanoparticles inhibit HCT116 colorectal cancer cells by inducing apoptosis, cell cycle arrest and ROS production
时间：2025-1-1
作者：Yongjing Hu; Ying Yin; Jiayan Shi; Ali Bahadur; Kamyar Shameli; Chenxiao Zheng; Xiaodong Zhang; Sin - Yeang Teow
杂志：Process Biochemistry
DOI：10.1016/j.procbio.2024.11.017
IF：3.7
Antimetastasis Effect of Astragalus membranaceus-Curcuma zedoaria via beta-Catenin Mediated CXCR4 and EMT Signaling Pathway in HCT116.
时间：2019-5-30
作者：Tan, Xiying;Xu, Mengting;Liu, Fuyan;Xu, Ming;Yao, Yi;Tang, Decai
杂志：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
DOI：10.1155/2019/9692350
IF：2.6
AEBP1, a prognostic indicator, promotes colon adenocarcinoma cell growth and metastasis through the NF-κB pathway
时间：2019-10-1
作者：Yanwei Xing;Zhiqiang Zhang;Fengxu Chi;Yang Zhou;Shuo Ren;Zhiwei Zhao;Yuekun Zhu;Daxun Piao
杂志：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23066
IF：3
6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway
时间：2023-1-1
作者：Min Chen;Chiin Tong;Qibiao Wu;Zhenghong Zhong;Qida He;Li Zeng;Lu Xiao
杂志：INTEGRATIVE CANCER THERAPIES
DOI：10.1177/15347354231172732
IF：2.9
METTL3 in cancer-associated fibroblasts-derived exosomes promotes the proliferation and metastasis and suppresses ferroptosis in colorectal cancer by eliciting ACSL3 m6A modification
时间：2024-8-19
作者：Hongtao Ren;Mincong Wang;Xiulong Ma;Lei An;Yuyan Guo;Hongbing Ma
杂志：BIOLOGY DIRECT
DOI：10.1186/s13062-024-00511-z
IF：5.7
LSM12 facilitates the progression of colorectal cancer by activating the WNT/CTNNB1 signaling pathway
时间：2023-2-9
作者：Yan Zhuang;Chunlan Ning;Pengfei Liu;Yanpeng Zhao;Yue LI;Zhenchi Ma;Luling Shan;Yingzhe Piao;Peng Zhao;Xun Jin
杂志：ONCOLOGY RESEARCH
DOI：10.32604/or.2022.028225
IF：2
IGF2BP3 is an essential N6-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells
时间：2022-12-15
作者：Xin Xu;Jiangtao Cui;Hong Wang;Lifang Ma;Xiao Zhang;Wanxin Guo;Xiangfei Xue;Yikun Wang;Shiyu Qiu;Xiaoting Tian;Yayou Miao;Mengyi Wu;Yongchun Yu;Yunhua Xu;Jiayi Wang;Yongxia Qiao
杂志：MATERIALS TODAY BIO
DOI：10.1016/j.mtbio.2022.100503
IF：8.7
FOXC2-induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression
时间：2023-8-1
作者：Junwei Zou;Yong Huang;Yuan Chen;Zhaoying Wu;Hao Xie;Hailang Zhou;Chungen Xing
杂志：IUBMB LIFE
DOI：10.1002/iub.2718
IF：3.7
Augmenting Tumor Lysis and Immune Response through HIFU-armed Oncolytic Virus Delivery System
时间：2025-4-
作者：Xifeng Qin; Mingyang Liu; Hu Wu; Boshu Ouyang; Xu Zhao; Xiaomin Su; Ruizhe Xu; Huiwen Liu; Jiayi Wu; Yue Liu; Ting Wang; Onder Ergonul; Füsun Can; Jia Li; Lin Lin; Funan Liu; Zhiqing Pang
杂志：NANO TODAY
DOI：10.1016/j.nantod.2024.102571
IF：13.2
Anticancer activity evaluation of indazolyl-substituted piperidin-4-yl-aminopyrimidines
时间：2020-5-1
作者：Chao Wang;XiaoWen Liu;Ting Xiao;ZhiQiang Xu;Shuang Cao;HaiFeng Wang;QiongJiao Yan;ShuangXi Gu;YuanYuan Zhu
杂志：MEDICINAL CHEMISTRY RESEARCH
DOI：10.1007/s00044-020-02531-6
IF：2.6
A positive feedback circuit between RN7SK snRNA and m6A readers is essential for tumorigenesis
时间：2023-6-7
作者：Xin Xu;Lifang Ma;Xiao Zhang;Susu Guo;Wanxin Guo;Yikun Wang;Shiyu Qiu;Xiaoting Tian;Yayou Miao;Yongchun Yu;Jiayi Wang
杂志：MOLECULAR THERAPY
DOI：10.1016/j.ymthe.2022.12.013
IF：12.1
FAM49B drives colorectal cancer progression by stabilizing c-Myc through NEK9 phosphorylation.
时间：2025-1-9
作者：Chen Lu;Tianyu Liu;E Yimin;Lin Miao;Chunzhao Yu;Jianping Zhang;Xiagang Luo
杂志：Biofactors
DOI：10.1002/biof.2158
IF：5
Hyodeoxycholic acid inhibits colorectal cancer proliferation through the FXR/EREG/EGFR axis.
时间：2025-1-21
作者：Qiang Pang;Shansong Huang;Xiaodong Li;Jiaqing Cao
杂志：Frontiers in Cell and Developmental Biology
DOI：10.3389/fcell.2024.1480998
IF：4.6
Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists.
时间：2025-3-17
作者：Hongyan Lin;Shuaijun Cui;Xinye Xu;Qingqing Chen;Jiazi Ge;Dongxuan Ai;Jie Zhu;Yuheng Tao;Liqun Wang;Lingyu Ruan;Wenhao Ge
杂志：BIOORGANIC CHEMISTRY
DOI：10.1016/j.bioorg.2025.108307
IF：4.5
Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping.
时间：2025-1-20
作者：Shansong Huang;Huiying Wang;Jiaqing Cao;Qiang Pang
杂志：Scientific Reports
DOI：10.1038/s41598-025-85809-2
IF：3.8
Inhibition of Colorectal Cancer Metastasis by Total Flavones of Abelmoschus manihot via LncRNA AL137782-mediated STAT3/EMT Pathway Regulation.
时间：2025-2-17
作者：Qian Li;Hui Zhang;Yongshan He;Hao Zhang;Conghui Han
杂志：CURRENT PHARMACEUTICAL DESIGN
DOI：10.2174/0113816128298998240828060306
IF：2.6
