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- 详细信息
- 技术资料
- 亚型:
IgG1
- 形态:
请咨询
- 保存条件:
Store at -20°C
- 标记物:
Unconjugated
- 适应物种:
Human, Mouse, Rat
- 保质期:
请咨询
- 级别:
仅用于科研
- 库存:
1 week
- 宿主:
Mouse
- 浓度:
请咨询
- 靶点:
SMAD1
- 规格:
100ul
| 背景 | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] |
|---|---|
| 别名 | BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1 |
| 推荐稀释比 | WB 1:2000 |
| 组分&重悬 | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| 纯化 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Uniprot ID | Q15797 |
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Anti-SMAD1 OTI4H4;Mouse mAb
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