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- DIMA
- DME909483
- 2025年07月14日
- Mouse
- Human, Mouse, Rat
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- 亚型：
IgG2a
- 形态：
请咨询
- 保存条件：
Store at -20°C
- 标记物：
Unconjugated
- 适应物种：
Human, Mouse, Rat
- 保质期：
请咨询
- 级别：
仅用于科研
- 库存：
1 week
- 宿主：
Mouse
- 浓度：
请咨询
- 靶点：
TGF beta Receptor II
- 规格：
100ul
| 背景 | This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] |
|---|---|
| 别名 | AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TGFbeta-RII; TGFR-2 |
| 推荐稀释比 | WB 1:2000, IHC 1:2000 |
| 组分&重悬 | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| 纯化 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Uniprot ID | P37173 |
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文献和实验11 Detection of TGF Type II Receptor Hotspot Mutations: The BAT-RII Assay
in the TGF-β pathway detected thus far is mutation of the type II receptor (RII) in colon cancers, particularly in tumors with defective mismatch repair or microsatellite instability (MSI) (3 –5 ). These RII mutations occur in a repetitive region of coding
Microsatellite Analysis of the Insulin-Like Growth Factor II Receptor in Colorectal Carcinomas
The insulin-like growth factor II (IGFII) growth control pathway is comprised of three major components: IGFII ligand, insulin-like growth factor I receptor (IGFIR), and insulin-like growth factor II receptor (IGFIIR ). IGFIR and IGFIIR work
Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
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