- 询价
- DIMA
- DME909262
- 2025年07月11日
- Mouse
- Human
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- 详细信息
- 技术资料
- 亚型：
IgG1
- 形态：
请咨询
- 保存条件：
Store at -20°C
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
请咨询
- 级别：
仅用于科研
- 库存：
1 week
- 宿主：
Mouse
- 浓度：
请咨询
- 靶点：
CD40
- 规格：
100ul
| 背景 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul |
|---|---|
| 别名 | Bp50; CDW40; p50; TNFRSF5 |
| 推荐稀释比 | WB 1:2000, IHC 1:150 |
| 组分&重悬 | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| 纯化 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Uniprot ID | P25942 |
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Anti-CD40 OTI8G5；Mouse mAb
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