- 询价
- DIMA
- 武汉
- DME900062
- 2025年07月15日
- Mouse
- Human, Mouse, Rat
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- 详细信息
- 技术资料
- 亚型：
IgG2b
- 形态：
请咨询
- 保存条件：
Store at -20°C
- 克隆性：
单克隆
- 标记物：
Unconjugated
- 适应物种：
Human, Mouse, Rat
- 保质期：
请咨询
- 级别：
仅用于科研
- 库存：
1 week
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Mouse
- 浓度：
请咨询
- 靶点：
Noggin
- 抗体英文名：
Anti-PSCA antibody(DM87); Rabbit mAb
- 抗体名：
Anti-PSCA antibody(DM87); Rabbit mAb
- 规格：
100ul
| 背景 | Noggin is a secreted polypeptide which binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, it may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. The results of the mouse knockout of the ortholog suggest that noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. |
|---|---|
| 别名 | SYM1; SYNS1; SYNS1A |
| 推荐稀释比 | WB 1:20000~40000, IHC 1:50, IF 1:100 |
| 组分&重悬 | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| 纯化 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Uniprot ID | Q13253 |
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Anti-Noggin OTI1H8；Mouse mAb
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