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- PME46519
- 2025年07月16日
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- 保存条件：
-80°C
- 保质期：
请咨询
- 英文名：
Human ORP150 (HYOU1) (NM_006389) Protein
- 库存：
1 week
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
50 ug
| 产品类别 | ECD Proteins |
|---|---|
| 靶点 | ORP150 |
| Uniprot ID | Q9Y4L1 |
| 背景 | The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
| 描述 | Purified recombinant protein of Human hypoxia up-regulated 1 (HYOU1), transcript variant 1, Leu33-end, with C-terminal His tag, secretory expressed in HEK293 cells, 50ug |
| 分子量 | 108.9kDa |
| 纯度 | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| 别名 | GRP-170; Grp170; HSP12A; IMD59; ORP-150; ORP150 |
| 标签 | C-HIS |
| 表达宿主 | HEK293 |
| 组分与重悬 | PBS, pH7.4, 10% glycerol. |
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