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- PME33402
- 2025年07月15日
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- 保存条件：
-80°C
- 保质期：
请咨询
- 英文名：
Human HAAO (NM_012205) Protein
- 库存：
1 week
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
20 ug
| 产品类别 | ECD Proteins |
|---|---|
| 靶点 | HAAO |
| Uniprot ID | P46952 |
| 背景 | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008] |
| 描述 | Recombinant protein of human 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) |
| 分子量 | 32.4 kDa |
| 纯度 | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| 别名 | 3-HAO; h3HAO; HAO; VCRL1 |
| 标签 | C-Myc/DDK |
| 表达宿主 | HEK293T |
| 组分与重悬 | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
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