9-deoxy-9-methylene-16,16-dime

9-脱氧-9-亚甲基-16,16-二甲基前列腺素E2(metenprost)是PGE2的强效类似物，体内半衰期延长。metenprost与其他各种前列腺素衍生物结合使用，可终止猴子的妊娠早期。一次肌肉注射含有0.5毫克metenprost和7.5毫克17-苯基三去甲PGF1α可非常有效地终止早期妊娠。这种前列腺素混合物对妊娠晚期的猴子无效。与PGE2和PGF1α相比，在猴子和大鼠中，metenprost不会导致发烧或胃肠道问题等不良副作用。9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (metenprost) is a potent analog of PGE2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, metenprost results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of metenprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimester of pregnancy. Metenprost, when compared to PGE2 and PGF1α, in monkey and rat, does not result in unwanted side effects such as fever or gastrointestinal problems.