Elesclomol

一种凋亡诱导剂和铜离子载体；浓度为500nM时，在Ramos(RA1)细胞中产生ROS和氧化应激反应基因表达；浓度为100nM时，破坏线粒体膜电位并诱导Ramos(RA1)细胞凋亡；通过将铜转运到MDA-MB-435细胞的线粒体内膜中，诱导铁死亡；在3.6mg/kg的剂量下，预载铜可增加脑线粒体铜和线粒体复合物IV水平、存活时间以及体重和脑重量，并防止斑驳斑驳的Menkes病小鼠模型的神经元形态变化An inducer of apoptosis and a copper ionophore; produces ROS and oxidative stress response gene expression in Ramos (RA 1) cells at 500 nM; disrupts the mitochondrial membrane potential and induces apoptosis in Ramos (RA 1) cells at 100 nM; induces ferroptosis by transporting copper into the inner mitochondrial membrane in MDA-MB-435 cells; preloaded with copper increases brain mitochondrial copper and mitochondrial complex IV levels, survival time, and body and brain weight, and prevents changes in neuronal morphology in a mottled-brindled mouse model of Menkes disease at 3.6 mg/kg.