2-Methylthioadenosine triphosp

P2X2和P2Y1受体激动剂；抑制大鼠肠粘膜中的GC-C（大肠杆菌耐热肠毒素存在下Ki=360µM）；在基于荧光的报告检测中，1µM浓度下诱导大鼠原代弓状核神经元钙内流；增加表达人类P2Y1受体的1321N1星形细胞瘤细胞中肌醇磷酸的积累（EC50=51nM）；抑制尿鸟苷蛋白诱导的大鼠尿流量和钠排泄增加。A P2X2 and P2Y1 receptor agonist; inhibits GC-C in rat intestinal mucosal membranes (Ki = 360 µM in the presence of E. coli heat-stable enterotoxin); induces calcium influx in primary rat arcuate nucleus neurons in a fluorescence-based reporter assay at 1 µM; increases inositol phosphate accumulation in 1321N1 astrocytoma cells expressing human P2Y1 receptors (EC50 = 51 nM); inhibits uroguanylin-induced increases in urine flow and sodium excretion in rats.