cis-2-(((9H-fluoren-9-yl)metho

The 1,5-Disubstituted Tetrazole Ring as a cis-Amide Bond Surrogate

that often have special biosynthetic pathways or unusual posttranslational modifications, N -methyl amino acids are common and may play a special role because of their conformational properties, including their proclivity for cis-trans isomerism of the amide bond

Synthesis of (2R, 3R, 4R, 5S)-5-tert-Butyloxycarbonylamino-3,4-Dihydroxy-2-1sopropyl-3,4-O,O-Isopropylidene-6-CyctohexyI-Hexanoic Acid

The dipeptidic dihydroxyethylene isostere (27, 3R , 4R , 5S )-5-tert -butyloxy-carbonylamino-3,4-dihydroxy-2-isopropyl-3,4-O,O -isoprop-ylidene-6-cyclohexyl-hexanoic acid, 15 , is a representative building block of an important class

Techniques to Measure Nucleic Acid-Protein Binding and Specificity: Nuclear Extract Preparations, DNase I Footprinting, and Mobility Shift Assays

DNA-protein interactions are the basis for the molecular mechanisms responsible for nucleic-acid replication, gene transcription, recombination, viral integration, and gene regulation in both normal and pathophysiological conditions