CDKN1A mouse monoclonal antibo

gene_symbol：CDKN1A
predicted_size：17.9 kDa
Uniprot ID：P38936
description：CDKN1A mouse monoclonal antibody, clone OTI7C8 (formerly 7C8)
clonality：Monoclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]
immunogen：Human recombinant protein fragment corresponding to amino acids 2-164 of human CDKN1A(NP_510867) produced in E.coli.
recommended_dilution：WB 1:2000, IHC 1:150
predicted_size：17.9 kDa
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
host_species：Mouse
applications：IHC, WB
reactivities：Human