Rabbit Polyclonal Anti-MFN2 An

gene_symbol：MFN2
predicted_size：Predicted: 83 kDa; Observed: 90 kDa
Uniprot ID：O9514
description：Rabbit Polyclonal Anti-MFN2 Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：Mitofusin 2 (MFN2) and the related protein MFN1 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN2 is ubiquitously expressed, and found in both the ER and outer mitochondrial membrane. MFN2 has two key domains: a coiled coil region that mediates MFN2 binding and a GTPase domain that likely plays a role in fusion (3,4). Both domains are essential for embryonic development and may play a role in the pathobiology of obesity. Overexpression of MFN2 causes mitochondrial dysfunction and cell death (5).
immunogen：MFN2 antibody was raised against a 17 amino acid peptide near the center of human MFN2. The immunogen is located within amino acids 250 - 300 of MFN2.
recommended_dilution：WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
predicted_size：Predicted: 83 kDa; Observed: 90 kDa
buffer：PBS containing 0.02% sodium azide.
host_species：Rabbit
applications：IF, IHC, WB
reactivities：Human, Mouse, Rat