Rabbit anti-FTH1 Polyclonal An

gene_symbol：FTH1
predicted_size：null
Uniprot ID：P2794
description：Rabbit anti-FTH1 Polyclonal Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：Ferritin (FTH) is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and bioavailable form. The assembled ferritin molecule, often referred to as a nanocage, can store up to 4,500 atoms of iron. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits made up of two types of polypeptide chains: ferritin heavy chain and ferritin light chain, each having unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). In addition to iron buffering, heavy chain ferritin also enhances thymidine biosynthesis. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia. The level of serum ferritin is markedly elevated in inflammation, malignancy, and iron overload disorders. Research studies have found that defects in ferritin proteins are also associated with several neurodegenerative diseases.
immunogen：Recombinant protein of human FTH1
recommended_dilution：WB 1:500 - 1:2000, IHC 1:50- 1:200, IF 1:50- 1:200
predicted_size：null
buffer：Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
host_species：Rabbit
applications：IF, IHC, WB
reactivities：Human, Mouse, Rat