ATF6 Rabbit Polyclonal Antibod

gene_symbol：ATF6
predicted_size：75 kDa
Uniprot ID：P1885
description：ATF6 Rabbit Polyclonal Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
immunogen：C term -peptide of human ATF6
recommended_dilution：WB 1:500 - 1:2000;IHC 1:50 - 1:100IF 1:50 - 1:200
predicted_size：75 kDa
buffer：Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
host_species：Rabbit
applications：IF, IHC, WB
reactivities：Human, Mouse, Rat