Anti-TERT Rabbit Polyclonal An

gene_symbol：TERT
predicted_size：null
Uniprot ID：O14746
description：Anti-TERT Rabbit Polyclonal Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity; encoded by this gene; and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence; as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair; since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
immunogen：Synthetic peptide corresponding to a region derived from 1118-1132 amino acids of human telomerase reverse transcriptase
recommended_dilution：IHC: 50-200 Positive control: Human tonsil Predicted cell location: Cytoplasm
predicted_size：null
buffer：PBS pH7.3, 0.05% NaN3, 50% glycerol
host_species：Rabbit
applications：IHC
reactivities：Human