Anti-GRPR Rabbit Polyclonal An

gene_symbol：GRPR
predicted_size：43 kDa
Uniprot ID：P355
description：Anti-GRPR Rabbit Polyclonal Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems; including release of gastrointestinal hormones; smooth muscle cell contraction; and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated; 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung; colon; and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
immunogen：Synthetic peptide corresponding to a region derived from 350-365 amino acids of Human gastrin-releasing peptide receptor
recommended_dilution：WB: 200-1000 WB positive control: Human hepatocellsular carcinoma tissue and A549 cells IHC: 50-200 Positive control: Human cervical cancer Predicted cell location: Cytoplasm
predicted_size：43 kDa
buffer：PBS pH7.3, 0.05% NaN3, 50% glycerol
host_species：Rabbit
applications：IHC, WB
reactivities：Human, Mouse, Rat