Rabbit Polyclonal ORAI1 Antibo

gene_symbol：ORAI1
predicted_size：null
Uniprot ID：Q96D31
description：Rabbit Polyclonal ORAI1 Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
immunogen：ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1. The immunogen is located within the last 50 amino acids of ORAI1.
recommended_dilution：WB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL
predicted_size：null
buffer：PBS containing 0.02% sodium azide.
host_species：Rabbit
applications：IF, IHC, WB
reactivities：Human, Mouse, Rat