- ￥2650 - 4300
- Solarbio
- 北京
- K011487M
- 2025年07月11日
- WB
- Mouse
- Human
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- 详细信息
- 技术资料
- 免疫原：
Recombinant protein of human Beclin 1
- 亚型：
Golgi apparatus trans-Golgi network membrane Peripheral membrane protein Note=Interaction with ATG14 promotes translocation to autophagosomes Expressed in dendrites and cell bodies of cerebellar Purkinje cells
- 形态：
液体
- 保存条件：
Store at -20℃.Avoid freeze/thaw cycles.
- 克隆性：
Monoclonal Antibody
- 适应物种：
Human
- 保质期：
咨询
- 抗原来源：
Recombinant protein of human GRB2
- 级别：
实验级别
- 库存：
咨询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Mouse
- 应用范围：
WB
- 浓度：
WB 1:1000-5000.IHC 1:250-1000.IF 1:50-500.
- 靶点：
Beclin 1
- 抗体英文名：
Anti-Beclin 1 Monoclonal Antibody
- 抗体名：
Anti-Beclin 1 Monoclonal Antibody
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥2650.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥4300.0 |
Beclin 1 also known as ATG6 or VPS30 interacts with various cofactors (e.g.Ambra1 Barkor (Atg14) Rubicon or UVRAG) to regulate the lipid kinase Vps34 and promote the formation of the BECLIN1-Vps34-Vps15 complex hence inducing autophagy.Its function (via the BH3 domain) is inhibited by Bcl-2 or Bcl-XL.Beclin 1 (BECN1) is a crucial molecule in the control of the autophagic activity and its activity is regulated by multiple mechanisms including the post-translational modification protein-protein interaction and subcellular localization.It plays a role in crosstalk between apoptosis and autophagy.It has been reported that Beclin 1 can be cleaved into fragments of 50 37 and 35 kDa during apoptosis.It is involved in many disorders including neurodegeneration and cancer (tumorigenesis).Beclin 1 is a mammalian tumor suppressor and its gene is monoallelically deleted in 75% of ovarian 50% of breast and 40% of prostate cancers.Decreased expression of Beclin 1 has also been observed in human brain and lung tumors.The level of Beclin 1 was decreased in the affected brain regions of patients with Alzheimer’s disease early in the disease process.Recent studies have also shown that gain and loss of Beclin 1 function affects the death of heart cells.
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