OriGene Neurofascin (NFASC) Ra

ProductName：Neurofascin (NFASC) Rabbit Monoclonal Antibody [Clone ID: OTIR8E12]
description：Nfasc155 Rabbit monoclonal antibody,clone OTIR8E12
symbol：Neurofascin
synonyms：NEDCPMD; NF; NRCAML
locusid：23114
Concentration：1 mg/ml
sub_category：Primary Antibodies
uniprot_id：O94856
Applications：WB
CNdelivery：2周
RecommendDilution：WB 1:5000
Reactivity：Human
Immunogen：Human recombinant protein fragment of human Nfasc155 (NP_001153804) produced in E.coli.
Purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation：Unconjugated
ProteinFamilies：Transmembrane
ProteinPathways：Cell adhesion molecules (CAMs)
GeneName：neurofascin
Background：This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
Buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
isotypes_filter：IgG
predicted_size：132.11 kDa