OriGene AMH Rabbit Monoclonal

ProductName：AMH Rabbit Monoclonal Antibody [Clone ID: OTIR1B8]
description：AMH Rabbit monoclonal antibody, clone OTIR1B8
symbol：AMH
synonyms：MIF; MIS
locusid：268
Concentration：1 mg/ml
sub_category：Primary Antibodies
uniprot_id：P03971
Applications：ELISA
CNdelivery：2周
RecommendDilution：ELISA 1:5000-10000
Reactivity：Human
Immunogen：Recombinant protein (26-560aa) of human AMH produced in HEK293
Purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation：Unconjugated
ProteinFamilies：Druggable Genome, Secreted Protein
ProteinPathways：Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
GeneName：anti-Mullerian hormone
Background：This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
Buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
isotypes_filter：IgG
predicted_size：59.17 kDa